Skip to main content

The Heart and Nitric Oxide

  • Chapter
Book cover Pathophysiology of Heart Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 168))

  • 160 Accesses

Abstract

Within recent years, nitric oxide has emerged as an important regulator of a number of processes connected with circulation, the central nervous system, and immunological defenses [1]. This chapter is primarily concerned with membrane-related activation of nitric oxide synthase (NOS) and with NOS activity in infarcted heart muscle.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Nathan C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J 6: 2051–3064.

    Google Scholar 

  2. Saito T, Wolf A, Menon N, Saeed M, Bing RJ. 1988. Lysolecithins as endothelium-dependent vascular smooth muscle relaxants that differ from endothelium-derived relaxing factor (nitric oxide). Proc Natl Acad Sci USA 85:8246–8250

    Article  PubMed  CAS  Google Scholar 

  3. Dudek R, Conforto A, Bing RJ. 1993. Lysophosphatidylcholine-induced vascular relaxation and production of cGMP are EDRF-mediated. Proc Soc Exp Biol Med 203:474–479.

    PubMed  CAS  Google Scholar 

  4. Darnell J, Lodish H, Baltimore D. 1990. Molecular Cell Biology, 2nd edition. W.H. Freeman: New York, pp. 500–504.

    Google Scholar 

  5. Bing RJ, Termin A, Conforto A, Dudek R, Hoffmann MR. 1993. Membrane function and vascular reactivity. Biosci Rep 13(2): 61–67.

    CAS  Google Scholar 

  6. Shier WT, Baldwin JH, Nilsen-Hamilton M, Hamilton RT, Thanassi NM. 1976. Regulation of guanylate and adenylate cyclase activities by lysolecithin. Proc Natl Acad Sci 73: 1586–1590.

    Article  PubMed  CAS  Google Scholar 

  7. Shier WT, Trotter JT. 1976. Stimulation of liver microsomal sialytransferase activity by lysolecithin. FEBS Lett 62:165–168.

    Article  PubMed  CAS  Google Scholar 

  8. Pollock JS, Forstermann U, Mitchell JA, Warner TD, Schmidt HHHW, Nakane M, Murad F. 1991. Purification and characterization of particulate endothelium derived relaxing factor synthase from cultured and native bovine endothelial cells. Proc Natl Acad Sci 88: 10480–10484.

    Article  PubMed  CAS  Google Scholar 

  9. Hibbs JB, Taintor RR, Vavrin Z, Rachlin EM. 1988. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157:87–94.

    Article  PubMed  CAS  Google Scholar 

  10. Lyons CR, Orloff GJ, Cuningham JM. 1992. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem 267:6370–6374.

    PubMed  CAS  Google Scholar 

  11. Sessa WC, Barber CM, Lynch KR. 1993. Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein. Circ Res 72:921–924.

    PubMed  CAS  Google Scholar 

  12. Pollock JS, Klinghofer V, Forstermann U, Murad F. 1992. Endothelial nitric oxide synthase is myristylated. FEBS Lett 309:402–404.

    Article  PubMed  CAS  Google Scholar 

  13. Kamps MP, Buss JE, Sefton BM. 1985. Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation. Proc Natl Acad Sci USA 82:4625–4628.

    Article  PubMed  CAS  Google Scholar 

  14. Dudek RR, Wildhirt SM, Suzuki H, Winder S, Bing RJ. 1995. Intracellular translocation of endothelial nitric oxide synthase by hysophosphatidylcholine. Pharm 50:257–260.

    Article  CAS  Google Scholar 

  15. Busconi L, Michel T. 1993. Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem 268(12):8410–8413.

    PubMed  CAS  Google Scholar 

  16. Connelly CM, Ngoy S, Schoen FJ, Apstien CS. 1992. Biomechanical properties of reperfused transmural myocardial infarcts in rabbits during the first week after infarction. Circ Res 71:401–413.

    PubMed  CAS  Google Scholar 

  17. Bing RJ, Conforto A, Dudek R, Wildhirt S, Pinto V. 1994. The role of endothelial cells in the regulation of vascular tone. Can J Cardiol 10 (Suppl A):37A.

    Google Scholar 

  18. Ward SM, Xue C, Shuttleworth W, Bredt DS, Snyder SH, Sanders KM. 1992. NADPH-diaphorase and nitric oxide synthase colocalization in enteric neurons of canine proximal colon. Am J Physiol 263:G277–G284.

    PubMed  CAS  Google Scholar 

  19. Klimaschewski L, Kummer W, Mayer B, Couraud JY, Preissler U, Philippin B, Heym C. 1992. Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart. Circ Res 71:1533–1537.

    PubMed  CAS  Google Scholar 

  20. Ursell PC, Mayes M. 1993. The majority of nitric oxide synthase in pig heart is vascular and not neural. Cardiovasc Res 27:1920–1924.

    Article  PubMed  CAS  Google Scholar 

  21. Tracey WR, Nakane M, Pollock JS, Forstermann U. 1993. Nitric oxide synthase in neuronal cells, macrophages and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH activity. Biochem Biophys Res Commun 195:1035–1040.

    Article  PubMed  CAS  Google Scholar 

  22. Wildhirt SM, Dudek RR, Pinto V, Shankar Narayan K, Giesler G, Bing RJ. In press. Histo and immunohisto-chemistry in the identification of nitrc oxide synthase activity in myocardial infarction.

    Google Scholar 

  23. Reimer KA, Jennings B. 1979. The “wavefront phenomenon” of myocardial ischemic death. II. Transmural progress of necrosis within the framework of ischemia bed size (myocardium at risk) and collateral flow. Lab Invest 40:633–644.

    PubMed  CAS  Google Scholar 

  24. Fishbein MC, Meerbaum S, Rit J, Lando U, Kanmatsuse K, Mercier JC, Corday E, Ganz W. 1981. Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique.

    Google Scholar 

  25. Evans HG, Lewis MJ, Shah AM. 1993. Interleukin-1β modulates myocardial contraction via dexamethasone sensitive production of nitric oxide. Cardiovasc Res 27:1486–1490.

    Article  PubMed  CAS  Google Scholar 

  26. Balligand JL, Ungureanu D, Kelly RA, Kobzik L, Pimentai D, Michel T, Smith TW. 1993. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest 91:2314–2319.

    Article  PubMed  CAS  Google Scholar 

  27. Gerschenson LE, Rotello RJ. 1992. Apoptosis: a different type of cell death. FASEB J 6:2450–2455.

    PubMed  CAS  Google Scholar 

  28. Albina JE, Cui S, Mateo RB, Reichner JS. 1993. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. 150:5080–5085.

    CAS  Google Scholar 

  29. Albina JE, Mills CD, Henry WL Jr, Caldwell MD. 1989. Regulation of macrophage physiology by 1-arginine: role of the oxidative 1-arginine deiminase pathway. J Immunol 143:3641.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Bing, R.J., Dudek, R., Wildhirt, S., Suzuki, H. (1996). The Heart and Nitric Oxide. In: Dhalla, N.S., Singal, P.K., Takeda, N., Beamish, R.E. (eds) Pathophysiology of Heart Failure. Developments in Cardiovascular Medicine, vol 168. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1235-2_33

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1235-2_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8525-0

  • Online ISBN: 978-1-4613-1235-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics