Abstract
Within recent years, nitric oxide has emerged as an important regulator of a number of processes connected with circulation, the central nervous system, and immunological defenses [1]. This chapter is primarily concerned with membrane-related activation of nitric oxide synthase (NOS) and with NOS activity in infarcted heart muscle.
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References
Nathan C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J 6: 2051–3064.
Saito T, Wolf A, Menon N, Saeed M, Bing RJ. 1988. Lysolecithins as endothelium-dependent vascular smooth muscle relaxants that differ from endothelium-derived relaxing factor (nitric oxide). Proc Natl Acad Sci USA 85:8246–8250
Dudek R, Conforto A, Bing RJ. 1993. Lysophosphatidylcholine-induced vascular relaxation and production of cGMP are EDRF-mediated. Proc Soc Exp Biol Med 203:474–479.
Darnell J, Lodish H, Baltimore D. 1990. Molecular Cell Biology, 2nd edition. W.H. Freeman: New York, pp. 500–504.
Bing RJ, Termin A, Conforto A, Dudek R, Hoffmann MR. 1993. Membrane function and vascular reactivity. Biosci Rep 13(2): 61–67.
Shier WT, Baldwin JH, Nilsen-Hamilton M, Hamilton RT, Thanassi NM. 1976. Regulation of guanylate and adenylate cyclase activities by lysolecithin. Proc Natl Acad Sci 73: 1586–1590.
Shier WT, Trotter JT. 1976. Stimulation of liver microsomal sialytransferase activity by lysolecithin. FEBS Lett 62:165–168.
Pollock JS, Forstermann U, Mitchell JA, Warner TD, Schmidt HHHW, Nakane M, Murad F. 1991. Purification and characterization of particulate endothelium derived relaxing factor synthase from cultured and native bovine endothelial cells. Proc Natl Acad Sci 88: 10480–10484.
Hibbs JB, Taintor RR, Vavrin Z, Rachlin EM. 1988. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157:87–94.
Lyons CR, Orloff GJ, Cuningham JM. 1992. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem 267:6370–6374.
Sessa WC, Barber CM, Lynch KR. 1993. Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein. Circ Res 72:921–924.
Pollock JS, Klinghofer V, Forstermann U, Murad F. 1992. Endothelial nitric oxide synthase is myristylated. FEBS Lett 309:402–404.
Kamps MP, Buss JE, Sefton BM. 1985. Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation. Proc Natl Acad Sci USA 82:4625–4628.
Dudek RR, Wildhirt SM, Suzuki H, Winder S, Bing RJ. 1995. Intracellular translocation of endothelial nitric oxide synthase by hysophosphatidylcholine. Pharm 50:257–260.
Busconi L, Michel T. 1993. Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem 268(12):8410–8413.
Connelly CM, Ngoy S, Schoen FJ, Apstien CS. 1992. Biomechanical properties of reperfused transmural myocardial infarcts in rabbits during the first week after infarction. Circ Res 71:401–413.
Bing RJ, Conforto A, Dudek R, Wildhirt S, Pinto V. 1994. The role of endothelial cells in the regulation of vascular tone. Can J Cardiol 10 (Suppl A):37A.
Ward SM, Xue C, Shuttleworth W, Bredt DS, Snyder SH, Sanders KM. 1992. NADPH-diaphorase and nitric oxide synthase colocalization in enteric neurons of canine proximal colon. Am J Physiol 263:G277–G284.
Klimaschewski L, Kummer W, Mayer B, Couraud JY, Preissler U, Philippin B, Heym C. 1992. Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart. Circ Res 71:1533–1537.
Ursell PC, Mayes M. 1993. The majority of nitric oxide synthase in pig heart is vascular and not neural. Cardiovasc Res 27:1920–1924.
Tracey WR, Nakane M, Pollock JS, Forstermann U. 1993. Nitric oxide synthase in neuronal cells, macrophages and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH activity. Biochem Biophys Res Commun 195:1035–1040.
Wildhirt SM, Dudek RR, Pinto V, Shankar Narayan K, Giesler G, Bing RJ. In press. Histo and immunohisto-chemistry in the identification of nitrc oxide synthase activity in myocardial infarction.
Reimer KA, Jennings B. 1979. The “wavefront phenomenon” of myocardial ischemic death. II. Transmural progress of necrosis within the framework of ischemia bed size (myocardium at risk) and collateral flow. Lab Invest 40:633–644.
Fishbein MC, Meerbaum S, Rit J, Lando U, Kanmatsuse K, Mercier JC, Corday E, Ganz W. 1981. Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique.
Evans HG, Lewis MJ, Shah AM. 1993. Interleukin-1β modulates myocardial contraction via dexamethasone sensitive production of nitric oxide. Cardiovasc Res 27:1486–1490.
Balligand JL, Ungureanu D, Kelly RA, Kobzik L, Pimentai D, Michel T, Smith TW. 1993. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest 91:2314–2319.
Gerschenson LE, Rotello RJ. 1992. Apoptosis: a different type of cell death. FASEB J 6:2450–2455.
Albina JE, Cui S, Mateo RB, Reichner JS. 1993. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. 150:5080–5085.
Albina JE, Mills CD, Henry WL Jr, Caldwell MD. 1989. Regulation of macrophage physiology by 1-arginine: role of the oxidative 1-arginine deiminase pathway. J Immunol 143:3641.
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© 1996 Kluwer Academic Publishers
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Bing, R.J., Dudek, R., Wildhirt, S., Suzuki, H. (1996). The Heart and Nitric Oxide. In: Dhalla, N.S., Singal, P.K., Takeda, N., Beamish, R.E. (eds) Pathophysiology of Heart Failure. Developments in Cardiovascular Medicine, vol 168. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1235-2_33
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DOI: https://doi.org/10.1007/978-1-4613-1235-2_33
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