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Regulation of Slow Ca2+ Channels of Myocardial Cells by Cyclic Nucleotides and Phosporylation

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Pathophysiology of Heart Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 168))

Abstract

Phosphorylation of ion channels is a means of regulating or modulating the activity of the channels. There is evidence for such regulation of function of Ca2+, K+, and Na+ channels by phosphorylation, and biochemical evidence shows that one or a few sites on the channel proteins can be phosphorylated by various protein kinases. Most of the physiological evidence for modulation of ion channel function by cyclic-nucleotide-dependent phosphorylation is for slow (L-type) Ca2+ channels of cardiac muscle, vascular smooth muscle (VSM), skeletal muscle, and nerve, and for K+ channels (delayed rectifier type) of cardiac muscle and nerve.

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Authors
  1. Nicholas Sperelakis
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  2. Kotaro Sumii
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Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla (Distinguished Professor), Pawan K. Singal (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor) &  (Professor Emeritus)

  2. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda (Associate Professor) (Associate Professor)

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© 1996 Kluwer Academic Publishers

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Sperelakis, N., Sumii, K. (1996). Regulation of Slow Ca2+ Channels of Myocardial Cells by Cyclic Nucleotides and Phosporylation. In: Dhalla, N.S., Singal, P.K., Takeda, N., Beamish, R.E. (eds) Pathophysiology of Heart Failure. Developments in Cardiovascular Medicine, vol 168. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1235-2_13

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  • DOI: https://doi.org/10.1007/978-1-4613-1235-2_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8525-0

  • Online ISBN: 978-1-4613-1235-2

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