Abstract
Assessment of regional myocardial blood flow at rest and after physiological or pharmacological stress is paramount in the diagnosis of coronary artery disease for assessment of interventions designed to improve nutritive perfusion and for delineation of the effects of noncoronary disease on myocardial perfusion.
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References
Bergmann SR. Quantification of myocardial perfusion with positron emission tomography. In: Bergmann SR, Sobel BE (eds): Positron Emission Tomography of the Heart. Mount Kisco, NY: Futura Publishing, 1992, pp 97–127.
de Jong RM, Blanksma PK, Willemsen ATM, Anthonio RL, Meeder JG, Pruim J, Vaalburg W, Lie KI. Posterolateral defect of the normal human heart investigated with nitrogen-13-ammonia and dynamic PET. J Nucl Med 35:581–585, 1995.
Krivokapich J, Smith GT, Huang S-C, Hoffman EJ, Ratib O, Phelps ME, Schelbert HR. 13N-ammonia myocardial imaging at rest and with exercise in normal volunteers. Circulation 80:1328–1337, 1989.
Hutchins GD, Schwaiger M, Rosenspire KC, Krivokapich J, Schelbert H, Kuhl DE. Noninvasive quantification of regional blood flow in the human heart using 13N-ammonia, and dynamic positron emission tomographic imaging. J Am Coll Cardiol 15:1032–1042, 1990.
Demer LL. Gould LK, Golstein RA, Kirkeeide RL, Mullani NA, Smalling RW, Nishikawa A, Merhige ME. Assessment of coronary artery disease severity by positron emission tomography. Comparison with quantitative arteriography in 193 patients. Circulation 79:825–835, 1989.
Goldstein RA, Kirkeeide RL, Demer LL, Merhige ME, Nishikawa A, Smalling RW, Mullani NA, Gould LK. Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man. J Clin Invest 79:1473–1478, 1987.
Herrero P, Markham J, Shelton ME, Bergmann SR. Implementation and evaluation of a two-compartment model for quantification of myocardial perfusion with rubidium-82 and positron emission tomography. Circ Res 70:496–507, 1992.
Herrero P, Markham J, Shelton ME, Weinheimer CJ, Bergmann SR. Nonivasive quantitation of regional myocardial blood flow with Rubidium-82, and positron emission tomography: Exploration of a mathematical model. Circulation 82:1377–1386, 1990.
Shelton ME, Green MA, Mathias CJ, Welch MJ, Bergmann SR. Kinetics of copper-PTSM in isolated hearts: A novel tracer for measuring blood flow with positron emission tomography. J Nucl Med 30:1843–1847, 1989.
Shelton ME, Green MA, Mathias CJ, Welch MJ, Bergmann SR. Assessment of regional myocardial and renal blood flow using copper-PTSM and positron emission tomography. Circulation 82:990–997, 1990.
Herrero P, Markham J, Weinheimer CJ, Anderson CJ, Welch MJ, Green MA, Bergmann SR. Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography. Circulation 87:173–183, 1993.
Bergmann SR, Fox KAA, Rand AL, McElvany KD, Welch MJ, Markham J, Sobel BE. Quantification of regional myocardial blood flow in vivo with H2 15O. Circulation 70: 724–733, 1984.
Walsh NM, Bergmann SR, Steele RL, Kenzora JL, Ter-Pogossian MM, Sobel BE, Geltman EM. Delineation of impaired regional myocardial perfusion by positron emission tomography with H15O. Circulation 78:612–620, 1988.
Kety S. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 3:1–41, 1951.
Hoffman EJ, Huang S-C, Phelps ME. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr 3:299–308, 1979.
Henze E, Huang S-C, Ratib O, Hoffman E, Phelps ME, Schelbert HR. Measurements of regional tissue and blood-pool radiotracer concentrations from serial tomographic images of the heart. J Nucl Med 24:987–996, 1983.
Herrero P, Markham J, Myears DW, Weinheimer CJ, Bergmann SR. Measurement of myocardial blood flow with positron emission tomography: Correction for count spillover and partial volume effects. Math Comput Model 11:807–812, 1988.
Bergmann SR, Herrero P, Markham J, Weinheimer CJ, Walsh MN. Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water, and positron emission tomography. J Am Coll Cardiol 14:639–652, 1989.
Iida H, Kanno I, Takahashi A, Miura S, Murakami M, Takahashi K, Ono Y, Shishido F, Inugami A, Tomura N, Higano S, Fujita H, Sasaki H, Nakamichi H, Mizusawa S, Kondo Y, Uemura K. Measurement of absolute myocardial blood flow with H2 15O and dynamic positron-emission tomography. Circulation 78:104–115, 1988.
Herrero P, Markham J, Bergmann SR. Quantitation of myocardial blood flow with H150 and positron emission tomography: Assessment and error analysis of a mathematical approach. J Comp Assist Tomogr 13:862–873, 1989.
Araujo LI, Lammertsma AA, Rhodes CG, McFalls EO, Iida H, Rechavia E, Galassi A, de Silva R, Jones T, Maseria A. Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography. Circulation 83:875–885, 1991.
Hack SN, Eichung JO, Bergmann SR, Sobel BE. External quantification of myocardial perfusion by exponential infusion of positron emitting radionuclides. J Clin Invest 66:918–927, 1980
Iida H, Rhodes CG, de Silva R, Araujo LI, Bloomfield PM, Lammertsma AA, Jones T. 1992. Use of the left ventricular time-activity curve as a noninvasive input function in dynamic oxygen-15-water, positron emission tomography. J Nucl Med 33:1669–1677, 1992.
Herrero P, Staudenherz A, Walsh JF, Gropler RJ, Bergmann SR. Heterogeneity of myocardial perfusion provides the physiological basis of perfusable tissue index. J Nucl Med 36:320–327, 1995.
Iida H, Rhodes CG, de Silva R, Yamamoto Y, Araujo LI, Maseri A, Jones T. Myocardial tissue fraction—correction for partial vlume effects and measure of tissue viability. J Nucl Med 32:2169–2175, 1991.
Bergmann SR, Weinheimer CJ, Toeniskoetter PD, Markham J, Staudenherz A, Walsh JF, Gropler FJ, Herrero P. Estimation of myocardial perfusion with PET and oxygen-15-water, administered by constant intravenous infusion (abstr). J Nucl Med 34:86, 1993.
Rechavia E, Araujo LI, de Silva R, Kushwaha R, Kushwaha SS, Lammerstma AA, Jones T, Mitchell A, Maseri A, Yacoub MH. Dipyridamole vasodilator response after human orthotopic heart transportation: Quantification by oxygen-15-labeled-water, and positron emission tomography. J Am Coll Cardiol 19:100–106, 1992.
Shelton ME, Senneff MJ, Ludbrook PA, Sobel BE, Bergmann SR. Concordance of nutritive myocardial perfusion reserve and flow velocity reserve in conductance vessels in patients with chest pain with angiographically normal coronary arteries. J Nucl Med 34:717–722, 1993.
Senneff MJ, Geltman EM, Bergmann SR. Noninvasive delineation of the effects of moderate aging on myocardial perfusion. J Nucl Med 32:2037–2042, 1991.
Walsh MN, Geltman EM, Steele RL, Kenzora JL, Ludbrook PA, Sobel BE, Bergmann SR. Augmented myocardial perfusion reserve after angioplasty quantified by positron emission tomography with H2 15O. J Am Coll Cardiol 15:119–127, 1990.
Henes CG, Bergmann SR, Perez JE, Sobel BE, Geltman EM. The time course of restoration of nutritive perfusion, myocardial oxyen consumption, and regional function after coronary thrombolysis. Cor Art Dis 1:687–696, 1990.
Senneff MJ, Hartman J, Sobel BE, Geltman EM, Bergmann SR. Persistence of coronary vasodilator responsivity after cardiac transplantation. Am J Cardiol 71:333–338, 1993.
Geltman EM, Henes CG, Senneff MJ, Sobel BE, Bergmann SR. Increased myocardial perfusion at rest and diminished perfusion reserve in patients with angina and angiographically normal coronary arteries. J Am Coll Cardiol 16:586–595, 1990.
Yamamoto Y, de Silva R, Rhodes CG, Araujo LI, Iida H, Rechavia E, Nihoyannopoulos P, Hackett D, Galassi AR, Taylor CJV, Lammerstma AA, Jones T, Maseri A. A new strategy for the assessment of viable myocardium and regional myocardial blood flow using 15O-water and dynamic positron emission tomography. Circulation 86:167–178, 1992.
de Silva R, Yamamoto Y, Rhodes CG, Iida H, Nihoyannopoulos P, Davies GJ, Lammertsma AA, Jones T, Maseri A. Preoperative prediction of the outcome of coronary revascularization using positron emission tomography. Circulation 86:1738–1742, 1992.
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Herrero, P., Bergmann, S.R. (1996). Assessment of Myocardial Perfusion with 15O-Water. In: Schwaiger, M. (eds) Cardiac Positron Emission Tomography. Developments in Cardiovascular Medicine, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1233-8_7
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DOI: https://doi.org/10.1007/978-1-4613-1233-8_7
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