Neohesperidine dihydrochalcone: recent findings and technical advances

  • M. G. Lindley


In the late 1950s, Gentili, working with Horowitz in the Western Regional Research Laboratory of the US Department of Agriculture, was preparing derivatives of phenolic glycosides as part of a programme to help in understanding the relationships between chemical structure and bitter taste. As part of this research project, neohesperidine dihydrochalcone was prepared from the flavanone neohesperidin. On tasting, neohesperidine DC was discovered to be sweet rather than bitter, and this led to a patent being issued to the USDA in 1963 (Horowitz and Gentili, 1963).


Sweet Taste Phenolic Glycoside European Patent Application Calorie Sweetener Western Regional Research Laboratory 
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© Chapman & Hall 1996

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  • M. G. Lindley

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