Abstract
Since the introduction of radioimmunoassays in the late 1950s and the widespread reliance on radioisotopic labels in various fields of clinical and medical science and practice during the 1960s and 1970s, rapid changes have occurred in label technology for immunoassays. Even though radioimmunoassays have their unquestionable advantages, certain of their limitations have created a strong demand to develop nonradioisotopic alternatives. Thus, alternative labels and techniques have been adopted primarily in order to obtain simpler or more sensitive assays that do not involve radioisotopes.
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Deshpande, S.S. (1996). Enzymes and Signal Amplification Systems. In: Enzyme Immunoassays. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1169-0_6
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