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Stromal-Epithelial Cell Interactions in Breast Cancer

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Dietary Fats, Lipids, Hormones, and Tumorigenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 399))

Abstract

The vast majority of breast cancers originate from breast ductal epithelial cells and are either infiltrating ductal or intraductal breast cancers (1). These cells exist in a local microenvironment in which both stromal cell products and blood-borne factors may influence both transformation and tumor growth. Breast ductal epithelial cells and stromal cells have a number of things in common. Both cell types produce protein growth factors and active steroids. At the same time both cell types respond to stimulation by peptides and steroids. This chapter will explore the hypothesis that these two cell types interact in both paracrine and endocrine fashion to affect breast epithelial growth, tumor development, and breast tumor metastasis.

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Author information

Authors and Affiliations

  1. Division of Clinical Nutrition, UCLA School of Medicine, 1000 Veteran Avenue, Los Angeles, California, 90095, USA

    David Heber, Judith Ashley & Dilprit Bagga

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  1. David Heber
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  2. Judith Ashley
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  3. Dilprit Bagga
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Editors and Affiliations

  1. University of California, Los Angeles, Philadelphia, California, USA

    David Heber

  2. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

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© 1996 Plenum Press, New York

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Heber, D., Ashley, J., Bagga, D. (1996). Stromal-Epithelial Cell Interactions in Breast Cancer. In: Heber, D., Kritchevsky, D. (eds) Dietary Fats, Lipids, Hormones, and Tumorigenesis. Advances in Experimental Medicine and Biology, vol 399. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1151-5_4

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  • DOI: https://doi.org/10.1007/978-1-4613-1151-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8450-5

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