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The Myasthenic Syndromes

  • Chapter
Molecular Biology of Membrane Transport Disorders

Abstract

This chapter deals with disorders of the neuromuscular junction including myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital disorders of neuromuscular transmission (CDNT). The pathophysiologies of these disorders lie at the presynaptic nerve terminal and the specialized structures located on the postsynaptic skeletal muscle membrane. The myasthenic syndromes are of general interest because an understanding of the pathophysiology at the neuromuscular junction may provide insight into disorders at other neural synapses as, for example, may occur in certain epileptic disorders. In addition, understanding the consequence of specific mutations in the nicotinic acetylcholine receptor (AChR), as occurs in some of the CDNT, may provide insights into the structure-function relationships of the AChR.

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Authors and Affiliations

  1. Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, USA

    Henry J. Kaminski & Robert L. Ruff

  2. Cleveland Veterans Affairs Medical Center, University Hospitals of Cleveland, Cleveland, Ohio, 44106, USA

    Henry J. Kaminski & Robert L. Ruff

  3. Department of Neuroscience, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, USA

    Robert L. Ruff

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  1. Henry J. Kaminski
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Editor information

Editors and Affiliations

  1. University of Texas Medical School at Houston, Houston, Texas, USA

    Stanley G. Schultz

  2. University of Arkansas College of Medicine, Little Rock, Arkansas, USA

    Thomas E. Andreoli

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Arthur M. Brown

  4. The Johns Hopkins University, Baltimore, Maryland, USA

    Douglas M. Fambrough

  5. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman

  6. University of Iowa College of Medicine, Iowa City, Iowa, USA

    Michael J. Welsh

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© 1996 Plenum Press, New York

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Kaminski, H.J., Ruff, R.L. (1996). The Myasthenic Syndromes. In: Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D.M., Hoffman, J.F., Welsh, M.J. (eds) Molecular Biology of Membrane Transport Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1143-0_28

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  • DOI: https://doi.org/10.1007/978-1-4613-1143-0_28

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