Skip to main content
SpringerLink
Log in

Molecular Mechanisms Involved in the Control of Differential Cytokine Expression in Human Monocytes

  • Chapter
Cytokines and Growth Factors in Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 32))

  • 62 Accesses

Abstract

During the last few years a tremendous increase has been obtained in our knowledge of cytokines. Apart from the identification of new cytokines we have reached a better understanding of cytokine gene regulation as well as of signal transduction pathways leading to cytokine gene expression. One of the intriguing phenomena of the regulation of cytokines is the specificity in effects of stimulatory agents which has been observed in different haematopoietic cells. This differential regulation of cytokines is most extensively studied in human monocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Nathan CF. Secretory products of macrophages. J Clin Invest 1987;79:319–26.

    Article  PubMed  CAS  Google Scholar 

  2. De Wit H, Esselink MT, Halie MR, Vellenga E. Differential regulation of M-CSF and IL-6 gene expression in monocytic cells. Br J Haematol 1994;86:259–64.

    Article  PubMed  Google Scholar 

  3. De Wit H, Dokter WHA, Esselink MT, Halie MR, Vellenga E. Interferon-γ enhances the LPS-induced G-CSF gene expression in human adherent monocytes which is regulated at transcriptional and post-transcriptional level. Exp Haematol 1993;21:785–90.

    Google Scholar 

  4. Horiguchi J, Warren MK, Kufe D. Expression of macrophage specific colony-stimulating factor in human monocytes treated with granulocyte-macrophage colony-stimulating factor. Blood 1987;69:1259–61.

    PubMed  CAS  Google Scholar 

  5. Vellenga E, Rambaldi A, Ernst TJ, Ostapovicz D, Griffin JD. Independent regulation of M-CSF and G-CSF gene expression in human monocytes. Blood 1988; 71:1529–32.

    PubMed  CAS  Google Scholar 

  6. Rambaldi A, Young DC, Griffin JD. Expression of the M-CSF (CSF-1) gene by human monocytes. Blood 1987;69:1409–13.

    PubMed  CAS  Google Scholar 

  7. Oster W, Lindemann A, Horn S, Mertelsmann R, Herrmann F. Tumour necrosis factor (TNF)-alpha but not TNF-beta induces secretion of colony-stimulating factor for macrophages (CSF-1) by human monocytes. Blood 1987;70:1700–3.

    PubMed  CAS  Google Scholar 

  8. Bauer J, Ganter U, Geiger T, et al. Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte derived macrophages. Blood 1988; 72:1134–40.

    PubMed  CAS  Google Scholar 

  9. Tosato G, Jones KD. Interleukin-1 induces interleukin-6 production in peripheral blood monocytes. Blood 1990;75:1305–10.

    PubMed  CAS  Google Scholar 

  10. Tuyt LML, de Wit H, Koopmans SB, Sierdsema SJ, Vellenga E. Effects of IL-3 and LPS on transcription factors involved in the regulation of IL-6 mRNA. Br J Haematol 1996;92:521–29.

    Article  PubMed  CAS  Google Scholar 

  11. Bernstein P, Ross J. Poly(A) binding protein and the regulation of mRNA stability. Trends biochem sci 1989;14:373–77.

    Article  PubMed  CAS  Google Scholar 

  12. Rambaldi A, Bettoni S, Rossi V, et al. Transcriptional and post-transcriptional regulation of IL-1β, IL-6 and TNF-α genes in chronic lymphocytic leukaemia. Br J Haematol 1993;83:204–11.

    Article  PubMed  CAS  Google Scholar 

  13. Pleszczynski MR, Stankova J. Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA acuumulation in human monocytes in vitro: transcriptional and post-transcriptional mechanisms. Blood 1992;80:1004–11.

    Google Scholar 

  14. Sehgal PB. Regulation of IL-6 gene expression. Res immunol 1992;143:724–34.

    Article  PubMed  CAS  Google Scholar 

  15. Tanabe O, Akira S, Kamiya T, et al. Genomic structure of the murine IL-6 gene: high degree conservation of potential regulatory sequences between mouse and human. J Immunol 1988;141:3875–81.

    PubMed  CAS  Google Scholar 

  16. Shimizu H, Mitomo K, Watanabe T, Okamoto S, Yamamoto K. Involvement of a NF-KB-like transcription factor in the activation of ithe interleukin-6 gene by inflammatory lymphokines. Mol Cell Biol 1990;10:561–68.

    PubMed  CAS  Google Scholar 

  17. Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-KB transcription factor. Mol Cell Biol 1990;10:2327–34.

    PubMed  CAS  Google Scholar 

  18. Akira S, Isshiki H, Nakajima T, et al. Regulation of expression of the interleukin-6 gene: structure and function of the transcription factor NF-IL6. CIBA Found Symp 1992;167:47–67.

    PubMed  CAS  Google Scholar 

  19. Akira S, Isshiki H, Sugita T, et al. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 1990;9:1897–906.

    PubMed  CAS  Google Scholar 

  20. Isshiki H, Akira S, Tanabe O, et al. Constitutive and IL-1 -inducible factors interact with the IL-1-response element in the IL-6 gene. Mol Cell Biol 1992;10:2757–64.

    Google Scholar 

  21. Curran T, Franza BR. Fos and jun: the AP-1 connection. Cell 1988;55:395.

    Article  PubMed  CAS  Google Scholar 

  22. Janaswami PM, Kalvakolanu DV, Zhang Y, Sen GC. Transcriptional repression of the interleukin-6 gene by adenoviral protein E1A. J Biol Chem 1992;267:24886–91.

    PubMed  CAS  Google Scholar 

  23. Grimm S, Baeuerle PA. The inducible transcription factor NF-KB: structure-function relationship of its protein subunits. Biochem J 1993;290:297–308.

    PubMed  CAS  Google Scholar 

  24. Müller JM, Ziegler Heitbrock HWL, Baeuerle PA. Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiol 1993;187:233–56.

    Google Scholar 

  25. Beg AA, Baldwin AS Jr. The IκB proteins: multifunctional regulators of Rel/NF-KB transcription factors. Genes Develop 1993;7:2064–70.

    Article  PubMed  CAS  Google Scholar 

  26. Cordle SR, Donald R, Read MA, Hawiger JJ. Lipopolysaccharide induces phosphorylationof MAD3 and activation of c-rel and related NF-KB proteins in human monocytic THP-1 cells. J Biol Chem 1993;268:11803–10.

    PubMed  CAS  Google Scholar 

  27. Henkel T, Machleidt T, Alkalay I, Krönke M, Ben-Nerlah Y, Baeuerle PA. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 1993;365:182–85.

    Article  PubMed  CAS  Google Scholar 

  28. Ihle JN, Witthuhn BA, Quelle FW, et al. Signaling by the cytokine receptor super-family: JAKs and STATs. Trends Biol Sci 1994;19:222–27.

    Article  CAS  Google Scholar 

  29. Ihle JN, Kerr IM. JAKs and STATs in signaling by the cytokine receptor superfamily. Trends Genet 1995; 11:69–74.

    Article  PubMed  CAS  Google Scholar 

  30. Darnell JE, Kerr IM, Stark GR. JAK/STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415–21.

    Article  PubMed  CAS  Google Scholar 

  31. Nakajima K, Yamanaka Y, Nakae K, et al. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in Ml leukemia cells. EMBO J 1996; 15: 3651–58.

    PubMed  CAS  Google Scholar 

  32. Finbloom DS, Winestock KD. IL-10 induces the tyrosine phosphorylation of Tyk2 and Jakl and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J Immunol 1995;155:1079–90.

    PubMed  CAS  Google Scholar 

  33. Tsukada J, Waterman WR, Koyama Y, Webb AC, Auron PE. A novel STAT-like factor mediates lipopolysaccharide, interleukin-1 (IL-1), and IL-6 signaling and recognizes a gamma interferon activation site-like element in the IL1β gene. Mol Cell Biol 1996;16:2183–94.

    PubMed  CAS  Google Scholar 

  34. Shuai K, Schindler C. Prezioso VR, Darneil JE. Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 1992;259:1808–12.

    Article  Google Scholar 

  35. Shuai K, Stark GR, Kerr IM, Darnell JE. A single phosphotyrosine residue Stat91 required for gene activation by interferon-γ. Science 1993;261:1744–46.

    Article  PubMed  CAS  Google Scholar 

  36. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. An inter-leukin-4-induced transcription factor: IL-4 Stat. Science 1994;265:1701–6.

    Article  PubMed  CAS  Google Scholar 

  37. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995;80:179–85.

    Article  PubMed  CAS  Google Scholar 

  38. Hunter T. Protein kinases and phosphatases: the Yin and Yang of protein phosphorylation and signaling. Cell 1995;80:225–36.

    Article  PubMed  CAS  Google Scholar 

  39. Nakajima T, Kinoshita S, Sasagawa T, et al. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci 1993;90:2207–11

    Article  PubMed  CAS  Google Scholar 

  40. Gille H, Kortenjann M, Thomae O, et al. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 1995;14:951–62.

    PubMed  CAS  Google Scholar 

  41. Gupta S, Campbell D, Derijard B, Davis RJ. Transcription factor ATF-2 regulation by the JNK signal transduction pathway. Science 1995;267:389–93.

    Article  PubMed  CAS  Google Scholar 

  42. Van Dam H, Wilhelm D, Herr I, et al. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J 1995;14:1798–811.

    PubMed  Google Scholar 

  43. Cavigelli M, Dolfi F, Claret F-X, Karin M. Induction of c-fos expression through JNK-mediated TCF-Elk-1 phosphorylation. EMBO J 1995:14:5957.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Haematology, Department of Medicine, University of Groningen, The Netherlands

    L. M. L. Tuyt & E. Vellenga

  2. Center for Biomedical Technology, Deparment of Medicine, University of Groningen, The Netherlands

    W. H. A. Dokter

Authors
  1. L. M. L. Tuyt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. H. A. Dokter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Vellenga
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Red Cross Blood Bank Noord Nederland, The Netherlands

    Cees Th. Smit Sibinga (Initiator and Organiser) & P. C. Das (Initiator and Organiser) & 

  2. Erasmus University, Rotterdam, The Netherlands

    Bob Löwenberg (Chairman) (Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Kluwer Academic Publishers

About this chapter

Cite this chapter

Tuyt, L.M.L., Dokter, W.H.A., Vellenga, E. (1997). Molecular Mechanisms Involved in the Control of Differential Cytokine Expression in Human Monocytes. In: Sibinga, C.T.S., Das, P.C., Löwenberg, B. (eds) Cytokines and Growth Factors in Blood Transfusion. Developments in Hematology and Immunology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1137-9_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1137-9_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8435-2

  • Online ISBN: 978-1-4613-1137-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation