Gene Therapy in Malignancies: Development and Clinical Applications of Autologous Tumour Vaccines
Various applications of therapeutically active cancer vaccines have recently been reviewed by Subiza et al. . In their opinion, concepts and tools related to such therapies are more clear than ever before and clinical results are encouraging. Accompanying editorials express somewhat contrasting views. In one editorial the need is expressed for a combination of antigen-specific effect targeting the immune reaction to tumour plus a systemic immuno- or endocrine-modulating effect to treat cancer , and in the potential of the other producing progression or only temporary benefit following vaccine therapy .
KeywordsToxicity Shrinkage Oncol
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- 1.Subiza JL, Cifuentes L, Medina MT. Prospects in cancer vaccines. Cancer J 1995; 8:293–98.Google Scholar
- 2.Fridman WH. Cancer vaccines — Myth or reality? Cancer J 1995;8:188–90.Google Scholar
- 3.Prehn RT. On the probability of effective anticancer vaccines. Cancer J 1995;8:284–85.Google Scholar
- 6.Simons J, Jaffee EM, Weber C, et al. Bioactivity of human GM-CSF gene transfer in autologous irradiated renal cell carcinoma vaccines. J Clin Oncol 1997 (in press).Google Scholar
- 7.Pardoll DM. GM-CSF transfected autologous RC vaccine. Presented at the NCI-EORTC Conference, March 1996, Amsterdam, The Netherlands.Google Scholar
- 8.Rankin E. Immunological effects of vaccination with autologous, GM-CSF transduced and irradiated tumor cells in patients with advanced melanoma. Presented at the NCI-EORTC Conference, March 1996, Amsterdam, The Netherlands.Google Scholar
- 9.Dranoff G. Granulocyte-macrophage colony stimulating factor based melanoma vaccines. Presented at the Molecular Medicine Society Conference, May 1996, Washington DC.Google Scholar