Skip to main content
SpringerLink
Log in

Peripheral Blood Progenitor Grafts Obtained from Healthy Donors

  • Chapter
Cytokines and Growth Factors in Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 32))

  • 66 Accesses

Abstract

After the first cases of allogeneic transplantation of G-CSF-primed peripheral blood prognitor cells (PBPC) had been reported a few years ago [1,2] the use of mobilized PBPC instead of BM as source of allogeneic stem cells has rapidly expanded [3]. The present article will elucidate the potential benefits and limitations of allogeneic PBPC with particular focus on collection and cellular composition of PBPC grafts obtained from healthy donors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dreger P, Suttorp M, Haferlach T, Schroyens W, Löffler H, Schmitz N. Allogeneic G-CSF-mobilised peripheral blood progenitor cells for treatment of engraftment failure after bone marrow transplantation. Blood 1993;81:1404–07.

    PubMed  CAS  Google Scholar 

  2. Russell NH, Hunter A, Rogers S, Hanley J, Anderson D. Peripheral blood stem cells as an alternative to marrow for allogeneic transplantation. Lancet, 1993;341:1482–82.

    Article  PubMed  CAS  Google Scholar 

  3. Gratwohl A, Hermans J, Baldomero H. Blood and marrow transplantation in Europe. Bone Marrow Transpl, 1997;19(in press).

    Google Scholar 

  4. Schmitz N, Linch, DC, Dreger P, et al. Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients. Lancet, 1996;347:353–57.

    Article  PubMed  CAS  Google Scholar 

  5. Smith TJ, Hillner BE, Schmitz N, et al. Economic analysis of a randomized trial to compare filgrastim-mobilized peripheral blood progenitor cell transplantation and autologous bone marrow transplantation in patients with Hodgkin and Non-Hodgkin lymphoma. J Clin Oncol 1997;15:5–10.

    PubMed  CAS  Google Scholar 

  6. Stroncek DF, Clay ME, McCullough J. Experiences of normal individuals treated with granulocyte colony stimulating factor. Blood 1994;84(Suppl-l):541a(Abstr).

    Google Scholar 

  7. Bensinger WI, Buckner CD, Rowley S, Storb R, Appelbaum, FR. Treatment of normal donors with recombinant growth factors for transplantation of allogeneic blood stem cells. Bone Marrow Transpl, 1996;17(Suppl 2):S19-S21.

    Google Scholar 

  8. Grigg AP, Roberts AW, Raunow H, et al. Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood 1995;86:4437–45.

    PubMed  CAS  Google Scholar 

  9. Dreger P, Haferlach T, Eckstein V. G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: Safety, kinetics of mobilization, and composition of the graft. Brit J Haematol, 1994;87:609–13.

    Article  CAS  Google Scholar 

  10. Azevedo WM., Aranha FJP, Gouvea JV, et al. Allogeneic transplantation with blood stem cells mobilized by rhG-CSF for haematological malignancies. Bone Marrow Transpl 1995;16:647–53.

    CAS  Google Scholar 

  11. Anderlini P, Przepiorka D, Seong D, Champlin R, Körbling M. Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis. Brit J Haematol 1996;94:155–58.

    Article  CAS  Google Scholar 

  12. Körbling M, Huh YO, Durett A, et al. Allogeneic blood stem cell transplantation: Peri-pheralization and yield of donor-derived primitive haematopoietic progenitor cells (CD34+ Thy-1) and lymphoid subsets, and possible predictors of engraftmcnt and graft-versus-host disease. Blood 1995;86:2842–48.

    PubMed  Google Scholar 

  13. Sakamaki S, Matsunaga T, Hirayama Y, Kuga T. Nitzsy Y. Haematological study of healthy volunteers 5 years after G-CSF. Lancet. 1995;346:1432–33.

    Article  PubMed  CAS  Google Scholar 

  14. Kawase Y, Akashi M, Ohtsu H, Aoki Y, Akanuma A, Suzuki G. Effect of human recombinant granulocyte colony-stimulating factor on induction of myeloid leukemias by X-irradiation in mice. Blood 1993;82:2163–68.

    PubMed  CAS  Google Scholar 

  15. Imashuku S, Hibi S, Nakajima F, et al. A review of 125 cases to determine the risk of myelodysplasia and leukemia in pediatric neutropenic patients after treatment with recombinant human granulocyte colony-stimulating factor. Blood 1994;84:2380–81.

    PubMed  CAS  Google Scholar 

  16. Kawakami M, Tsutsumi H, Kumakawa T, et al.Levels of serum granulocyte colony-stimulating factor in patients with infections. Blood 1990;76:1962–64.

    PubMed  CAS  Google Scholar 

  17. Dreger P, Glass B, Uharek L, Zeis M, Schmitz N. Allogeneic transplantation of mobilized peripheral blood progenitor cells: Towards tailored cell therapy. Int J Hematol 1997 (in press).

    Google Scholar 

  18. Dreger P, Oberböster K, Schmitz N. PBPC grafts from healthy donors: Analysis of CD34+ and CD3+ subpopulations. Bone Marrow Transpl 1996;17(Suppl 2): S22-S27.

    Google Scholar 

  19. Bacigalupo A, van Lint MT, Valbonesi M, et al. Thiotepa/cyclophosphamide followed by granulocyte colony-stimulating factor mobilized allogeneic peripheral blood cells in adults with advanced leukemia. Blood, 1960;88:353–57.

    Google Scholar 

  20. Urbano-Ispizua A, Solano C, Brunei S, et al. Allogeneic peripheral blood progenitor cell transplantation: Analysis of short-term engraftment and acute GvHD incidence in 33 cases. Bone Marrow Transpl 1996;18:35–40.

    CAS  Google Scholar 

  21. Russell JA, Luider J, Weaver M, et al.Collection of progenitor cells for allogeneic transplantation from peripheral blood of normal donors. Bone Marrow Transpl 1995; 15:111–15.

    Article  CAS  Google Scholar 

  22. Buckner CD, Petersen FB, Bolonesi BA. Bone marrow donors. Forman S J, Blume KG, Thomas ED (eds) Bone marrow transplantation. Blackwell Scientific Publications, Boston 1994:259

    Google Scholar 

  23. Harada M, Nagafuji K, Fujisaki T, et al. G-CSF-induced mobilization of peripheral blood stem cells from healthy adults for allogeneic transplantation. J Haematother 1996;5:63–71.

    Article  CAS  Google Scholar 

  24. Molineux G, Pojda. Z, Hampson LN, Lord BL, Dexter TM. Transplantation potential of peripheral blood stem cells induced by granulocytic colony-stimulating factor. Blood 1990;76:2153–158.

    PubMed  CAS  Google Scholar 

  25. Ottinger HD Beelen DW, Scheulen B, Schaefer UW, Grosse-Wilde H. Improved immune reconstitution after allotransplantation of periphcral blood stem cells instead of bone marrow. Blood 1996;88:2775–79.

    PubMed  CAS  Google Scholar 

  26. Pan L, Delmonte J, Jalonen CK, Ferrara JLM. Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T-lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood 1995;86:4422–29.

    PubMed  CAS  Google Scholar 

  27. Glass B, Uharek L, Zeis M, Löffler H, Müller-Ruchholtz W, Gassmann W. Graft-versus-leukemia activity can be predicted by natural cytotoxicity against leukemia cells. Brit J Haematol 1996;93:412–20.

    Article  CAS  Google Scholar 

  28. Schmitz N, Dreger P, Suttorp M, et al. Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (G-CSF). Blood 1995;85:1666–72.

    PubMed  CAS  Google Scholar 

  29. Körbling M, Przepiorka D, Engel H, et al. Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: Potential advantage of blood over marrow allografts. Blood 1995;85:1659–65.

    PubMed  Google Scholar 

  30. Bensinger WI, Weaver CH, Appelbaum FR, Buckner CD. Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor (rhG-CSF). Blood 1995; 85:1655–58.

    PubMed  CAS  Google Scholar 

  31. Bensinger WI, Buckner CD. Storb R, Demirer T, Appelbaum FA. Transplantation of allogeneic peripheral blood stem cells. Bone Marrow Transpl 1996;17(Suppl 2): S56-S57.

    Google Scholar 

  32. Schmitz N, Bacigalupo A, Labopin M, et al. Transplantation of allogeneic peripheral blood progenitor cells: The EBMT experience. Bone Marrow Transpl 1996; 17 (Suppl 2):S40-S46.

    Google Scholar 

  33. Elmaagacli AH, Beelen DW. Becks HW, et al. Molecular studies of chimerism and minimal residual disease after allogeneic peripheral blood progenitor cell or marrow transplantation. Ann Hematol, 1996;73(Suppl 2);84(Abstr).

    Google Scholar 

  34. Zeis M, Uharek L, Glass B, Steinmann J, Dreger P, Schmitz N. Superior graft-vs-leukemia effects after transplantation of murine allogeneic peripheral blood progenitor cells (PBSC) as compared to bone marrow. Blood 1996;88(Suppl l):245a(Abstr).

    Google Scholar 

  35. Müller-Ruchholtz W, Wottge HU, Müller-Hermelink HK. Bone marrow transplantation across strong histocompatibility barriers by selective elimination of lymphoid cells in bone marrow. Transplant Proc 1976;8:537–41.

    PubMed  Google Scholar 

  36. Dreger P, Viehmann K, Steinmann J. G-CSF-mobilised peripheral blood progenitor cells for allogeneic transplantation: Comparison of T cell depletion strategies using different CD34+ selection systems or CAMPATH-1. Exp Hematol 1995;23:147–154.

    PubMed  CAS  Google Scholar 

  37. Bensinger WI, Buckner CD, Rowley S, Demirer T, Storb R, Appelbaum FA. Transplantation of allogeneic CD34+ peripheral blood stem cells (PBSC) in patients with advanced haematologic malignancy. Bone Marrow Transpl 1996; 17(Suppl 2): S38-S39.

    Google Scholar 

  38. Corringham RET, Ho AD. Rapid and sustained allogeneic transplantation using immunoselected CD34+-selected peripheral blood progenitor cells mobilized by recombinant granulocyte-and granulocyte-macrophage colony-stimulating factors. Blood 1995;86:2052–54.

    PubMed  CAS  Google Scholar 

  39. Link H, Arseniev L, Bähre O, Kadar JG. Diedrich.H, Poliwoda H. Transplantation of allogeneic CD34+ blood cells. Blood 1995:87.4903–09.

    Google Scholar 

  40. Martelli MF, Aversa F, Velardi A, et al. New tools for crossing the HLA barrier: Fludarabine and megadose stem cell transplants. Blood 1996;8.8(Suppl 1)484a(Abstr).

    Google Scholar 

Download references

Authors
  1. P. Dreger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Schmitz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Red Cross Blood Bank Noord Nederland, The Netherlands

    Cees Th. Smit Sibinga (Initiator and Organiser) & P. C. Das (Initiator and Organiser) & 

  2. Erasmus University, Rotterdam, The Netherlands

    Bob Löwenberg (Chairman) (Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Kluwer Academic Publishers

About this chapter

Cite this chapter

Dreger, P., Schmitz, N. (1997). Peripheral Blood Progenitor Grafts Obtained from Healthy Donors. In: Sibinga, C.T.S., Das, P.C., Löwenberg, B. (eds) Cytokines and Growth Factors in Blood Transfusion. Developments in Hematology and Immunology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1137-9_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1137-9_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8435-2

  • Online ISBN: 978-1-4613-1137-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation