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Coronary Arterial Response to Injury

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Atlas of Interventional Cardiology

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Abstract

Both stent implantation and simple balloon angioplasty induce marked injury in the coronary artery or peripheral vessels. The artery’s response to that injury is critical to the long-term success or failure of the procedures [1–3]. The coronary artery responds to injury incurred during revascularization with neointimal hyperplasia, forming neointima of varying thickness, and with thickening of the adventitia. This latter process frequently causes vessel shrinkage, or negative remodeling, and is a principal cause of restenosis when a stent is not present to resist the constriction [4–8]. When a stent is placed, neointimal hyperplasia is the determining factor for in-stent restenosis and is the major target of drug-eluting stents. Presented in this chapter are animal models and human examples of the coronary artery’s response to injury during revascularization procedures.

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Authors
  1. Robert S. Schwartz
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  2. Renu Virmani
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  3. Andrew Farb
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Editor information

Editors and Affiliations

  1. Cardiac Catheterization Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Mayo Medical School, Rochester, Minnesota, USA

    David R. Holmes Jr. MD (Professor of Medicine, Director, Consultant) (Professor of Medicine, Director, Consultant)

  2. Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Mayo Medical School, Rochester, Minnesota, USA

    Verghese Mathew MD (Assistant Professor of Medicine, Consultant) (Assistant Professor of Medicine, Consultant)

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© 2003 Springer Science+Business Media New York

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Schwartz, R.S., Virmani, R., Farb, A. (2003). Coronary Arterial Response to Injury. In: Holmes, D.R., Mathew, V. (eds) Atlas of Interventional Cardiology. Current Medicine Group, London. https://doi.org/10.1007/978-1-4613-1091-4_1

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  • DOI: https://doi.org/10.1007/978-1-4613-1091-4_1

  • Publisher Name: Current Medicine Group, London

  • Print ISBN: 978-1-4757-0808-0

  • Online ISBN: 978-1-4613-1091-4

  • eBook Packages: Springer Book Archive

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