Immunotoxins pp 255-277 | Cite as

Immunotoxins: Selection of cell-surface antigens and their corresponding monoclonal antibodies

  • Michael J. Bjorn
  • C. L. Villemez
Part of the Cancer Treatment and Research book series (CTAR, volume 37)

Abstract

Immunotoxins (ITs) are complex molecules. To be effective, they must have a number of desirable features relating to the linker, the toxin component, the antibody component, and the target antigen, to name just a few. Other chapters in this volume have discussed linkers and toxins. This chapter will focus on target antigens and their corresponding monoclonal antibodies. Discussion will be limited primarily to ITs, defined as an antibody coupled to a protein toxin (including A chains and hemitoxins), although mention will also be made of antigen-toxin conjugates.

Keywords

Lymphoma Leukemia Sarcoma Disulfide Pseudomonas 

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Michael J. Bjorn
  • C. L. Villemez

There are no affiliations available

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