Proteases and Antiproteases at Different Vascular Sites in Renal Failure
A potential role of proteases in the pathogenesis of the catabolic state in patients with post-traumatic acute renal failure (ARF) has been discussed 1-3. It was suggested that active proteases might play a role in protein wasting observed in uremic conditions4. Since trauma itself might lead to increased plasma proteolysis, the present study was performed both in patients with non-traumatic ARF and chronic renal failure (CRF) to examine potential imbalances between proteases and antiproteases in plasma. Some components of plasma proteolytic enzyme systems were also studied. All parameters were measured in plasma taken at different vascular sites in order to establish as to whether there were any arteriovenous differences across various organs indicating local extraction or release.
KeywordsCatheter Creatinine Trypsin Plasminogen Uremia
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- 2.W.H. Hörl, J. Stepinski and A. Heidland, Further evidence for the participation of proteases in protein catabolism during hypercatabolic renal failure, in; “Acute renal failure”, H.E. Eliahou, ed., John Libbey, London (1982)Google Scholar