Abstract
Neutrophil granulocytes are a main component of the non-specific defence system. In order to destroy invading microorganism leukocytes must be able to leave the blood vessels and to have access to the microorganism in the surrounding connective tissue. The leukocytes must thus have the enzymatic capacity to penetrate the basement membrane which lines the vascular lumen and to degrade interstitial collagen. The same enzymatic capacity to degrade extracellular matrices is obviously a prerequisite for the metastasis of malignant cells.
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References
S. J. Weiss and G. J. Peppin, Collagenolytic metalloenzymes of the human neutrophil, Biochem. Pharmacol. 24:3189 (1986).
J. Fedrowitz, H. W. Macartney, and H. Tschesche, Human polymorphonuclear leukocyte gelatinase - a metalloproteinase, Hoppe-Seylers Z. Physiol. Chem. 364:1121 (1983).
I. Sopata and A. M. Dancewicz, Presence of a gelatin-specific proteinase and its latent form in human leucocytes, Biochim. Biophys. Acta 370:510 (1974).
M. Hibbs, K. A. Hasty, J. M. Seyer, A. H. Kang, and C. L. Mainardi, Biochemical and immunological characterisation of the secreted forms of human neutrophil gelatinase, J. Biol. Chem. 260:2493 (1985).
D.J. Pipoly and E. C. Crouch, Degradation of native typeIV procollagen degradation of basement membranes,Biochemistry, 260:5748 (1987).
G. Murphy, J. J. Reynolds, U. Bretz, and M. Baggiolini, Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes, Biochem. J.
J. Rauterberg, K. Kühn, Acid soluble calf skin collagen, Eur. J. Biochem
J. Rauterberg, H. Allman, W. Henkel, P. P. Fietsek, Isolation and charakrerization of CNBr derived peptides of the 1(III) chain of pepsin solubilized calf skin collagen, Hoppe Seyler’s Z. Physiol. Chem. 357:1401 (1976).
E. J. Miller, R. K. Rhodes, Preparation and charakterization of the different types of collagen, Methods Enzymol. 82:33 (1982).
R. Jander, J. Rauterberg, and W. Glanville, Further charakterization of the three polypeptide chains of bovine and human short-chain collagen (intima collagen), Eur. J. Biochem. 133:39
C. L. Mainardi, S. N. Dixit, A. N. Kang, Degradation of type IV (basement membrane)collagen by a proteinase isolated from human polymorphonuclear leukocyte granules, J. Biol. Chem. 255:5435 (1980).
H. Tschesche, H. W. Macartney, and J. Fedrowitz, Gelatinase, in:“Methods of enzymatic analysis Vol. V”, H. U. Bergmeyer, ed., Verlag Chemie, Weinheim (1984).
H. Tschesche and H. W. Macartney, Collagenase, in:“Methods of enzymatic analysis Vol. V”, H. U. Bergmeyer, ed., Verlag Chemie, Weinheim (1984).
Y. Masui, T. Takemoto, S. Sakakibara, H. Hori, and Y. Nagai, Synthetic substrates for vertebrate collagenase, Biochem. Med. 17:215 (1977).
S. Engelbrecht, E. Pieper, H.W. Macartney, W. Rautenberg, H. R., Wenzel, and H. Tschesche, Separation of the human leucocyte enzymes alanine aminopeptidase, cathepsin G, collagenase, elastase and myeloperoxidase, Hoppe-Seylers Z. Physiol. Chem. 363:305 (1982).
H. -J. Böhme, G. Kooperschläger, J. Schulz, and E. Hofmann, Affinity chromatography of phosphofructokinase using cibacron blue F3G-A, J. Chromatogr. 69:209 (1972).
F. W. Studier, Analysis of bacteriophage T7 early RNAs and proteins on slab gels, J. Mol. Biol. 79:237 (1973).
J. Heukeshoven, R. Dernick, Simplified method for silver staining of proteins in polyacrylamide gels and the mechanism of silver staining, Elektrophoresis 6:103 (1985).
J. Rautenberg, K. Kühn, Electron microscopic method of ordering the cyanogen bromide peptides of the 1 chain from acid soluble calfskin collagen, FEBS Letters 1:230 (1968)
J. Fedrowitz, Isolierung und Charakterisierung von Gelatinase aus menschlichen Leukocyten, PhD Thesis, Universität Bielefeld (1986).
G. Murphy, U. Bretz, M. Baggiolini, and J. J. Reynolds, The laten collagenase and gelatinase of human polymorphonuclear neutrophil leucocytes, Biochem. J. 192:517 (1980).
I. Sopata, Further purification and some properties of a gelatin-specific proteinase of human leucocytes, Biochim. Biophys. Acta 717:26 (1982)
S. Rantala-Ryhänen, L. Ryhänen, F. V. Nowak, J. Uitto, Proteinases in human polymorphonuclear leucocytes, Eur. J. Biochem. 134:129 (1983).
H. G. Welgus, G. P. Stricklin, Human skin fibroblast collagenase inhibitor, J. Biol. Chem. 258:12259 (1983).
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© 1988 Plenum Press, New York
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Kohnert, U., Oberhoff, R., Fedrowitz, J., Bergmann, U., Rauterberg, J., Tschesche, H. (1988). The Degradation of Collagen by a Metalloproteinase from Human Leucocytes. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_4
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DOI: https://doi.org/10.1007/978-1-4613-1057-0_4
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