Proteases II pp 267-273 | Cite as

Relation Between Urinary Proteinases and Proteinuria in Rats with a Glomerular Disease

  • Jean-Claude Davin
  • Malcolm Davies
  • Jean-Michel Foidart
  • Jacqueline B. Foidart
  • Charles A. Dechenne
  • Philippe R. Mahieu
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 240)


Electronegative charges of the glomerular filtration barrier play probably an important role in its impermeability to anionic proteins 1–9. Sialic acid 10 (present in laminin) and glycosaminoglycans 11 seem to be the major molecules responsible for this propriety. Neutral proteinases synthetized either by mesangial cells or by monocytes and neutrophils, infiltrating glomeruli in some pathologic states, are able to degrade GBM glycoproteins in vitro 12–14.


Mesangial Cell Glomerular Basement Membrane Neutral Proteinase Glomerular Filtration Barrier Glomerular Capillary Wall 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jean-Claude Davin
    • 1
    • 2
  • Malcolm Davies
    • 1
    • 2
  • Jean-Michel Foidart
    • 1
    • 2
  • Jacqueline B. Foidart
    • 1
    • 2
  • Charles A. Dechenne
    • 1
    • 2
  • Philippe R. Mahieu
    • 1
    • 2
  1. 1.Department of Medicine, Pediatrics and GynecologyState University of LiegeLiegeBelgium
  2. 2.Kidney Research Unit Foundation for WalesWelsh National Scholl of Medicine, Royal InfirmaryCardiffWales, UK

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