Induction of the Proteinase Inhibitor α2-Macroglobulin in Rat Hepatocytes by a Monocyte-Derived Factor
Disturbances of the physiologic homeostasis such as infections, tissue injury, tumor growth and immunologic disorders lead to a highly complex reaction of the organism, the so called acute-phase response1-3. The acute-phase response is characterized by fever, leukocytosis, a negative nitrogen balance, depression of serum iron and zinc levels, elevation of serum copper and dramatic changes in the synthesis of hepatic acute-phase proteins4,5. The plasma concentration of the proteinase inhibator α2-macroglobulin (α2M) or example increases 100-500-fold in the rat during acute inflammation. The concentration of the proteinase-inhibitor α1-inhibitor3 (α1I3) belonging to the same macroglobulin family decreases to about 30% simultaneousely. These changes are generated by mediators secreted from mononuclear phagocytes. Hepatocyte-stimulating factor (HSF), interleukin 1 (IL-1), tumor necrosis factor α (TNFα) and interferon ß (IFN ß) are the most important of theses mediators.
KeywordsZinc Hydrogen Peroxide Filtration Depression Albumin
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