Abstract
Intracellular proteolysis is necessary to adapt the protein composition of cells to environmental changes, to correct errors in transcription or in traslation, to degrade inactive pre- and pro-peptides and to liberate amino acids as an energy source from superfluous protein molecules in case of need1.
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References
P.Bohley, Intracellular proteolysis, in: New Comprehensive Biochemistry, A. Neuberger , and K.Brocklehurst, eds., Amsterdam, 1987, Elsevier, 16, p. 307
J.C.Waterlow, P.Garlick, and D.J.Millward, Protein turnover in mammalian tissues and in the whole body, Amsterdam, 1978, North Holland Publ. Co.
J.S.Bond, and R.J.Beynon, Proteolysis and physiological regulation, Mol. Aspects Med. 9: 173 (1987).
F. Wold, In vivo chemical modification of proteins, Annu.Rev.Biochem. 50: 783 (1981).
P.Walter, R.Gilmore, and G.Blobel, Protein translocation across the endoplasmatic reticulum, Cell 38: 5 (1984).
D.N.Wheatley, S.Grisolia, and J.Hernandez-Yago, Significance of the rapid degradation of newly synthesized proteins in mammalian cells : a working hypothesis, J.Theoret.Biol. 98: 283 (1982).
A.L. Goldberg, and A.C. St. John, Intracellular protein degradation in bacterial and mammalian cells. Part 2, Annu.Rev.Biochem. 45: 747 (1976).
J.S.Bond, and P.E.Butler, Intracellular proteases, Annu.Rev.Biochem. 56: 333 (1987).
S.Pontremoli, and E.Melloni, Extralysosomal protein degradation, Annu. Rev.Biochem. 55: 455 (1986).
R.T.Dean, and A.J.Barrett, Lysosomes, Essays Biochem. 12: 1 (1976).
H.Kirschke, J. Langner, B.Wiederanders, S.Ansorge, and P.Bohley, Cathepsin L. A new proteinase from rat liver lysosomes, Eur.J.Biochem. 74: 293 (1977).
A.J.Barrett, and H.Kirschke, Cathepsin B, Cathepsin H, and Cathepsin L, Methods Enzymol. 80: 535 (1981).
H.Kirschke, and A.J.Barrett, Cathepsin L - a lysosomal cysteine proteinase, in: Intracellular protein catabolism V, E.Khairallah, J.S.Bond, and J.W.C.Bird, eds., New York, 1985, Alan R. Liss Inc., Progr.Clinical and Biol.Res. 180, p. 61
P.Bohley, C.Hieke, H.Kirschke, and S.Schaper, Protein degradation in rat liver cells, in: Intracellular protein catabolism V, E.Khairallah, J.S. Bond, and J.W.C.Bird, eds., New York, 1985, Alan R.Liss Inc., Progr. Clinical and Biol.Res. 180, p. 447
H.Kirschke, A.A.Khembhavi, P.Bohley, and A.J.Barrett, Action of rat liver cathepsin L on collagen and other substrates, Biochem.J. 201: 367 (1982).
H.Kirschke, and E.Shaw, Rapid inactivation of cathepsin L by Z-Phe-Phe-CHN2 & Z-Phe-Ala-CHN2, Biochem.Biophys.Res.Commun. 101: 454 (1981).
S.Riemann, H.Kirschke, B.Wiederanaers, A.Brouwer, E.Shaw, and P.Bohley, Inhibition of cysteine proteinase activity by Z-Phe-Phe-diazomethane and of aspartic proteinase activity by pepstatin in different organs from some animals and isolated cells from rat liver, Acta Biol.Med.Germ. 41: 83 (1982).
Y.Bando, E.Kominami, and N.Katunuma, Purification and tissue distribution of rat cathepsin L, J.Biochem. 100: 35 (1986).
D.A.Portnoy, A.H.Erickson, J.Kochan, J.V.Ravetch, and J.C.Unkeless, Cloning and characterization of a mouse cysteine proteinase, J.Biol.Chem. 261: 14697 (1986).
P.Bohley, Intrazelluläre Proteolyse, Naturwissenschaften 55: 211 (1968).
P.Bohley, H.Kirschke, J.Langner, M.Miehe, S.Riemann, Z.Salama, E.Schon, B.Wiederanders, and S.Ansorge, Intracellular protein turnover, in: Biological functions of proteinases,30. Mosbach-Colloquium, H.Holzer, and H.Tschesche, eds., Berlin, Heidelberg, New York, 1979, SpringerVerlag, p. 17
P.Bohley, and S.Riemann, Intracellular protein catabolism IX: Hydrophobicity of substrate proteins is a molecular basis of selectivity, Acta Biol.Med.Germ. 36: 1823 (1977).
D.Finley, and A.Varshavsky, The ubiquitin system: functions and mechanisms, Trends Biochem.Sci. 10: 343 (1985).
E.R.Stadtmann, Oxidation of proteins by mixed-function oxidation systems: implication in protein turnover, ageing and neutrophil function, Trends Biochern.Sci. 11: 11 (1986).
A.J.Rivett, Regulation of intracellular proteinturnover: Covalent modification as a mechanism of marking proteins for degradation, Curr.Top.Cell.Regul. 28: 291 (1986).
A.Bachmair, D.Finley, and A.Varshavsky, In vivo half-life of a protein is a function of its amino-terminal residue, Science 234: 179 (1986).
S.Rogers, R.Williams, and M.Rechsteiner, Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis, Science 234: 364 (1986).
R.L.Soffer, Enzymatic Modification of Proteins II. Purification and properties of the arginyl transfer ribonucleic acid - protein transferase from rabbit liver cytosol, J.Biol.Chem. 245: 731 (1970).
R.L.Soffer, Aminoacyl-tRNA transferases, Enzymes 40: 91 (1974).
A.Ciechanover, S.L.Wolin, J.A.Steitz, and H.F.Lodish, Transfer RNA is an essential component of the ubiquitin- and ATP-dependent proteolytic system, Proc.Natl.Acad.Sci.USA 82: 1341 (1985).
R. Gebhardt , and W.Jung, Biliary secretion of sodium fluorescein in primary monolayer cultures of adult rat hepatocytes and its stimulation by nicotinamide, J.Cell Sci. 56: 233 (1982).
P.Bohley, J.Kopitz, and G.Adam, Surface hydrophobicity, arginylation and degradation of cytosol proteins from rat hepatocytes, Biol.Chern.Hoppe-Seyler (submitted for publication).
H.Hanson, Peptidasen (Exopeptidasen), in: Handbuch der physiologischund pathologisch-chemischen Analyse, 10.Aufl., Hoppe-Seyler/Thierfelder, Berlin, Heidelberg, New York, 1966, Springer-Verlag, Band VI/C p.l
A.Stock, S.Clarke, C.Clarke, and J.Stock, Review Letter: N-terminal methylation of proteins: structure, function and specificity, FEBS Letters 220: 8 (1987).
R.Katznelson, and R.G.Kulka, Degradation of microinjected methylated and unmethylated proteins in hepatoma tissue culture cells, J.Biol.Chem. 258: 9597 (1983).
R.J.Mayer, and F.Doherty, Review Letter: Intracellular protein catabolism: State of the art, FEBS Letters 198: 181 (1986).
P.J.A.M. Plomp, E.J.Wolvetang, A.K.Groen, A.J.Meijer, P.B.Gordon, and P.O.Seglen, Energy dependence of autophagic protein degradation in isolated rat hepatocytes, Eur.J.Biochem. 164: 197 (1987).
M.C.Duque-Magalhães, and J.M.Gualberto, Regulation of mitochondrial proteolysis. Selective degradation of inner membrane polypeptides, FEBS Letters 210: 142 (1987).
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© 1988 Plenum Press, New York
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Bohley, P., Kopitz, J., Adam, G. (1988). Arginylation, Surface Hydrophobicity and Degradation of Cytosol Proteins from Rat Hepatocytes. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_20
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DOI: https://doi.org/10.1007/978-1-4613-1057-0_20
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