Regulation of Drosophila Chorion Gene Amplification
The ability of animal and plant chromosomes to faithfully reduplicate remains poorly understood. In contrast, bacterial and viral chromosome replication has been elucidated in detail. DNA replication in these systems initiates at specific origin sequences following the binding of proteins that facilitate assembly of an active complex of replication enzymes. RNA transcripts produced at or near the origin sometimes also participate in controlling replicon initiation. Today, the question of whether similar control mechanisms govern the replication of chromosomes in higher organisms represents one of the most important issues in eukaryotic chromosome research.
KeywordsReplication Fork Replication Origin Follicle Cell Chorion Gene SV40 Enhancer
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