Mitogenic Effect of High Density Lipoprotein (HDL) on Lymphoblastoid Cells Involved HMG-CoA Reductase Activity
Preliminary data (1) have demonstrate that B-lymphocytes transformed by Epstein-Barr virus maintened with LPDS require the presence of lipoproteins in order to proliferate optimaly. Of the two classes of lipoproteins (HDL and LDL) that have been studied, HDL seems to be the major factor involved in the proliferation of the lymphoblastoid cells (LC). This is mostly due to the lack of toxicity when added at high concentration (however at high HDL concentration it presents low stimulating effect), the non-dependence on plasma to exhibited its mitogenic effect, the role played by total HDL apoproteins. Mitogenic effect is also realize in other cells type as bovine vascular endothelial cells, corneal endothelial cells (2, 3).
KeywordsCholesterol Synthesis Cholesterol Biosynthesis Mitogenic Effect Corneal Endothelial Cell Mevalonic Acid
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