Alkane Storage Disease (Very Long Chain N-Alkanes): An Original Type of Lipid Storage of Dietary Origin from Plant Wax Hydrocarbons

  • Christophe Duboucher
  • Francis Rocchiccioli
  • Anne Nègre
  • Alice Lageron
  • Robert Salvayre
Part of the NATO ASI Series book series (NSSA, volume 150)


We have recently reported a unique case of a new type of lipid storage disorder (Duboucher et al., 1986; Rocchiccioli et al., 1987) which we have named Alkane Storage Disease. This novel human morbid entity is characterized by the visceral accumulation of odd-numbered long chain n-alkanes. These alkanes are characteristic of vegetal cuticular waxes and differ from those present in mineral oil paraffin (Lester, 1979; Levade et al., 1987). The nature of the stored compounds, their visceral distribution and the clinical anamnesis strongly suggest a dietary origin. We also discuss the hypothetical metabolic defect which may cause the n-alkane accumulation and the pathophysiological mechanism explaining their tissular distribution.


Nile Blue Abdominal Lymph Node Dietary Origin Lipoid Pneumonia Exogenous Lipoid Pneumonia 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Christophe Duboucher
    • 1
  • Francis Rocchiccioli
    • 2
  • Anne Nègre
    • 3
  • Alice Lageron
    • 4
  • Robert Salvayre
    • 3
  1. 1.Laboratoire d’Anatomie Pathologique, CHU RangueilToulouse CedexFrance
  2. 2.Inserm U 188, Hôpital Saint-Vincent-de-PaulParisFrance
  3. 3.Laboratoire de Biochimie Médicale et Inserm U 101, Faculté de MédecineToulouseFrance
  4. 4.Inserm U 9ParisFrance

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