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Alkane Storage Disease (Very Long Chain N-Alkanes): An Original Type of Lipid Storage of Dietary Origin from Plant Wax Hydrocarbons

  • Christophe Duboucher
  • Francis Rocchiccioli
  • Anne Nègre
  • Alice Lageron
  • Robert Salvayre
Part of the NATO ASI Series book series (NSSA, volume 150)

Abstract

We have recently reported a unique case of a new type of lipid storage disorder (Duboucher et al., 1986; Rocchiccioli et al., 1987) which we have named Alkane Storage Disease. This novel human morbid entity is characterized by the visceral accumulation of odd-numbered long chain n-alkanes. These alkanes are characteristic of vegetal cuticular waxes and differ from those present in mineral oil paraffin (Lester, 1979; Levade et al., 1987). The nature of the stored compounds, their visceral distribution and the clinical anamnesis strongly suggest a dietary origin. We also discuss the hypothetical metabolic defect which may cause the n-alkane accumulation and the pathophysiological mechanism explaining their tissular distribution.

Keywords

Nile Blue Abdominal Lymph Node Dietary Origin Lipoid Pneumonia Exogenous Lipoid Pneumonia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Christophe Duboucher
    • 1
  • Francis Rocchiccioli
    • 2
  • Anne Nègre
    • 3
  • Alice Lageron
    • 4
  • Robert Salvayre
    • 3
  1. 1.Laboratoire d’Anatomie Pathologique, CHU RangueilToulouse CedexFrance
  2. 2.Inserm U 188, Hôpital Saint-Vincent-de-PaulParisFrance
  3. 3.Laboratoire de Biochimie Médicale et Inserm U 101, Faculté de MédecineToulouseFrance
  4. 4.Inserm U 9ParisFrance

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