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Expression of Presynaptic Calcium Channels in Xenopus Oocytes

  • Joy A. Umbach
  • Cameron B. Gundersen

Abstract

The release of neurotransmitter from nerve terminals is triggered by the influx of calcium ions through voltage-activated channels1–3. In excitable tissues there appear to be a number of different types of Ca channels, based on physiological parameters (single channel conductance, ion selectivity, voltage-dependent activation and inactivation properties) and sensitivity to pharmacological agents (especially dihydropyridines, w-conotoxin (wCgTx) and Cd ions). The type of Ca channel underlying synaptic transmission has not been established, although recent studies of mammalian neurons suggest that N-type channels are involved4, 22.

Keywords

Xenopus Oocyte Electric Organ Control Oocyte Tetraethylammonium Bromide Inactivation Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Joy A. Umbach
    • 1
  • Cameron B. Gundersen
    • 1
  1. 1.Department of Pharmacology and Jerry Lewis Neuromuscular Research CenterUCLA School of MedicineLos AngelesUSA

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