Abstract
In his modest little textbook on Animal Physiology (2nd Edition, W.H. Freeman and Co., New York, $32.95) Roger Eckert (1983) devotes 12.2 cm of text to the potassium-buffering function of neuroglia (see glial cells). Indeed, the selective permeability of glial cells to K+ and the role of glial cells in K+ homeostasis in the neuronal microenvironment has been reasonably well established during the past 20 years (Kuffler, 1967; Coles, 1985). More recently, evidence has accumulated indicating that glial cells may express voltage sensitive channels, albeit at low density, to other ions, including Na, CI“, and Ca (for review see Ransom and Carlini, 1986). However, such channels appear to open at membrane potentials far removed from those naturally occurring in glial cells; there is no evidence they participate in glial function.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Astion, M.L., Obaid, A.L., Orkand, R.K. and Salzberg, B.M.,1986, Barium block of potassium channels in glial cells of mudpuppy (Necturus maculosus) optic nerve: evidence from studies with microelectrodes and voltage sensitive dyes. Soc. Neurosci. Abstr. 12:164.
Astion, M.L., Coles, J.A. and Orkand R.K., 1987, Effects of bicarbonate on glial cell membrane potential in Necturus optic nerve. Neurosci. Lett. 76:47.
Bullock, T.H., Orkand, R. and Grinnell, A., 1977, “Introduction to Nervous Systems,” W. H. Freeman, San Francisco.
Bracho, H., Orkand, P.M. and Orkand, R.K., 1975, A further study of the fine structure and membrane properties of neuroglia in the optic nerve of Necturus. J. Neurobiol. 6:395.
Burckhardt, B.Ch., Cassola, A.C. and Fromter, E., 1984, Electrophysiological analysis of bicarbonate permeation across the peritubular cell membrane of rat kidney proximal tubule. II. Exclusion of HCO3 - effects on other ion permeabilities and of coupled electroneutral HCO3 transport. Pflugers Arch. 401:43.
Coles, J.A., 1985, Homeostasis of extracellular fluid in retinas of invertebrates and vertebrates. Prog. Sensory Physiol., 6:105.
Deitmer, J.W. and Schlue, W-R., 1987, The regulation of intracellular pH by identified glial cells and neurones in the central nervous system of the leech. J. Physiol. In Press.
Eckert, R., “Animal Physiology”, 2nd Ed. W.H. Freeman, San Francisco (1983).
Kettenmann, H., Orkand, R.K. and Lux, H.D., 1984, Some properties of potassium channels in cultured oligodendrocytes. Pflugers Arch. 400:215.
Kuffler, S.W., 1967, Neuroglial cells: physiological properties and a potassium mediated effect of neuronal activity on glial membrane potential. Proc. Roy. Soc. B., 168:1.
Ransom, B.R. and Carlini, W.G.,1986, Electrophysiological properties of astrocytes, in “Astrocytes, Vol.2” A. Vernadakis ed., Academic Press, New York.
Saito, Y. and Wright, E.M., 1984, Regulation of bicarbonate transport across the brush border membrane of the bull-frog choroid plexus. J. Physiol. 350:327.
Tang. C-M., Orkand, P.M. and Orkand, R.K., 1985, Coupling and uncoupling of amphibian neuroglia. Neurosci. Lett. 54:237.
Thomas, R.C., 1984, Experimental displacement of intracellular pH and the mechanism of its subsequent recovery. J. Physiol. 354:3P.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Orkand, R.K. (1988). Evidence for a Bicarbonate Conductance in Neuroglia. In: Grinnell, A.D., Armstrong, D., Jackson, M.B. (eds) Calcium and Ion Channel Modulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0975-8_31
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0975-8_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8273-0
Online ISBN: 978-1-4613-0975-8
eBook Packages: Springer Book Archive