Abstract
In comparison with other metals and metalloids, relatively little is known about the mechanisms by which elements such as indium and thallium, of Group III of the Periodic Table of elements, produce cell injury. Arsine gas (ASH3) has been known for centuries to be a potent hemolytic agent but the exact mechanism of this effect is still not understood at the molecular level. In recent years, the use of compounds containing some of the Group III elements and arsenic generated by processes utilizing arsine gas has expanded greatly due to the excellent electrical properties of these materials. This change in both the qualitative and quantitative patterns of use for these elements has increased the need for basic mechanistic toxicity data on Group III elements and arsine gas in relation to development of early biological indicators for assessing both exposure and toxicity.
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References
Barrera, H. and Gomez-Puyou, A., 1975, Characteristic of the movement of K+ across the mitochondrial membrane and the inhibitory action of T1+, J. Biol. Chem., 250: 5370–5374.
Bulmer, F.M.R., Rothwell, H.E. and Polack S.S. et al., 1940, Chronic arsine poisoning among workers employed in the cyanide extraction of gold: A report of fourteen cases, J. Indus. Hygiene Toxicol., 22: 111–124.
Castronovo, F.P., 1970, Factors affecting the toxicity of the element indium, Doctoral Thesis, Johns Hopkins University, 73 pp.
Castronovo, F.P. and Wagner, H.N., 1971, Factors affecting the toxicity of the element indium, Brit. J. Exp. Pathol., 52: 543–549.
Downs, W.L., Scott, J.L., Steadman, L.T. and Maynard, E.A., 1959, The toxicity of indium, University of Rochester Atomic Energy Project Report No. UR 558. University of Rochester, Rochester, NY, 57 pp.
Fowler, B.A., 1977, The toxicology of environmental arsenic, in: “Toxicology of Trace Elements,” R.A. Goyer and M.A. Mehlman, eds., pp. 79–122, Hemisphere Publishing Co., Washington, D.C.
Fowler, B.A., 1982, Indium and thallium and health, in: “Trace Elements and Health,” J. Rose, ed., pp. 74–82, I.P.C. Science and Technology Press, London.
Fowler, B.A., 1986, Indium, in: “Handbook on the Toxicology of Metals, Vol. 2,” L. Friberg, G.F. Norcfberg and V. Vouk, eds., 2nd Ed., pp. 267–275, Elsevier North Holland Biomedical Press, Amsterdam.
Fowler, B.A. and Weissberg, J.B., 1974, Arsine poisoning, New Eng. J. Med., 291: 1171–1174.
Fowler, B.A. and Woods, J.S., 1977, The transplacental toxicity of methylmercury to fetal rat liver mitochondria: Morphometric and biochemical studies, Lab. Invest., 122–130.
Fowler, B.A., Brown, H.W., Lucier, G.W. and Krigman, M.R., 1975, The effects of chronic oral methylmercury exposure on the lysosome system of rat kidney. Morphometric and biochemical studies, Lab. Invest., 32: 313–322.
Fowler, B.A., Woods, J.S. and Schiller, C.M., 1979, Studies of hepatic mitochondrial structure and function: Morphometric and biochemical evaluation of in vivo perturbation by arsenate, Lab. Invest., 41: 313–320.
Fowler, B.A., Kardish, R. and Woods, J.S., 1983, Alteration of hepatic microsomal structure and function by acute indium administration: U1trastructural morphometric and biochemical studies, Lab. Invest., 48: 471–478.
Gebert, F., 1937, Uber die reaktion zwischen Arsenwasserstoff und hamoglobin, Biochem. Z., 293: 157–186.
Gehring, P.J. and Hammond, P., 1964, The uptake of thallium by rabbit erythrocytes, J. Pharmacol. Exper. Therap., 145: 215–221.
Gramer, L., 1955, Uber eine todliche perakute Arsenwasserstoffvergiftung, Arch. Gewerbe Path. Gewerbehyg., 13: 601–610.
Hughes, W. and Levvy, G.A., 1947, The toxicity of arsine to tissue slices, Biochem. J., 41: 8–11.
Hultin, T. and Naslund, P.H., 1974, Effects of thallium (I) on the structure and functions of mammalian ribosomes, Chem. Biol. Interact., 8: 315–328.
Johnson, G.A., 1953, An arsine problem: Engineering notes, Amer. Indus. Health Assoc. Q., 14: 188–190.
Jung, F., 1939, Loslichkeit und reaktionsweise des Arsenwasserstoffs in Blut, Biochem. Z., 302: 294–309.
Kensler, C.J., Abels, J.C. and Rhoads, C.P., 1946, Arsine poisoning, mode of action and treatment, J. Pharmacol. Exper. Therap., 88: 99–108.
Labes, V.R., 1937, Die oxidative und reduktive Entstehung von kolloiden Elementen der Arsen-und Tellurgruppe als Urasache zahlreicher Giftwerkungen von ASH3, H2S, Te02, use. auf Zell strukturen und Fermente des Tierkorpers, Kolloid Zeitschrift, 79: 1–10.
Levinsky, W.J., Smalley, R.V., Hillyer, P.N. and Schindler, R.L., 1970, Arsine hemolysis, Arch. Env. Health, 20: 436–440.
Mahaffey, K.R., Capar, S.G., Gladen, B.C. and Fowler, B.A., 1981, Concurrent exposure to lead, cadmium, and arsenic: Effects on toxicity and tissue metal concentrations in the rat, J. Lab. Clin Med., 98: 463–481.
Melnick, R.L., Monti, R.G. and Motzkin, S.M., 1976, Uncoupling of mitochondrial oxidative phosphorylation by thallium, Biochem. Biophys. Res. Commun., 69: 68–73.
Naslund, PH. and Hultin, T., 1981, Selectivity of univalent cations with mammalian ribosomes studied by equilibrium dialysis in the presence of the K+ analogue 204T1+, J. Inorganic Biochem., 14: 67–79.
Oskarsson, A. and Fowler, B.A., 1986, Effects of lead on the heme biosynthetic pathway in rat kidney, Exper. Mol. Pathol, 43: 397–408.
Smith, I.C., Carson, B.C. and Hoffmeister, F., 1978, Indium, in: “Trace Elements in the Environment,” Vol. 5, 552 pp., Ann ArborTcience Publishers, Ann Arbor, Michigan.
Squibb, K.S. and Fowler, B.A., 1983, Biochemical mechanisms of arsenical toxicity, in: “Biological and Environmental Effects of Arsenic,” B.A.Fowler, ed., pp. 233–270, Elsevier North-Holland Biomedical Press, Amsterdam.
Stern, H.S., Goodwin, D.A. Schieffel, U. and Kramer, H.H., 1966, 113In for blood pool and brain scanning, Nucleonics, 25:62–65.
Woods, J.S. and Fowler, B.A., 1977, Renal porphyrinuria during chronic methylmercury exposure, J. Lab. Clin. Med., 90: 266–272.
Woods, J.S. and Fowler, B.A., 1978, Altered regulation of mammalian hepatic heme biosynthesis and urinary porphyrin excretion during prolonged exposure to sodium arsenate, Toxicol. Appl. Pharmacol., 43: 361–371.
Woods, J.S. and Fowler, B.A., 1982, Selective inhibition of renal ALA dehydratase by indium: Biochemical and ultrastructural studies, Exper. Molec. Pathol., 36: 306–315.
Woods, J.S. and Fowler, B.A., 1986, Alterations of hepatocellular structure and function by thallium chloride: Ultrastructural morphometric and biochemical studies, Toxicol. Appl. Pharmacol., 83: 218–229.
Woods, J.S., Carver, G.T. and Fowler, B.A., 1979, Altered regulation of hepatic heme metabolism by indium chloride, Toxicol. Appl. Pharmacol., 49: 455–461.
Woods, J.S., Fowler, B.A. and Eaton, D.L., 1984, Studies on the mechanisms of thallium-mediated inhibition of hepatic mixed function oxidase activity. Correlation with inhibition of NADPH-cytochrome c (P450) reductase, Biochem. Pharmacol., 33: 571–576.
Yoshikawa, H. and Hasegawa, T., 1971, Experimental indium poisoning, Igaku To Seibutsugaku, 93: 45–58.
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© 1988 Plenum Press, New York
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Fowler, B.A. (1988). Mechanisms of Indium, Thallium, and Arsine Gas Toxicity: Relationships to Biological Indicators of Cell Injury. In: Clarkson, T.W., Friberg, L., Nordberg, G.F., Sager, P.R. (eds) Biological Monitoring of Toxic Metals. Rochester Series on Environmental Toxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0961-1_22
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DOI: https://doi.org/10.1007/978-1-4613-0961-1_22
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