Cytogenetic and Genetic Alterations during Hepatocarcinogenesis
The study of the cancer phenotype, should from the theoretical point of view, be considered as the study of any other phenotype. It is the result of the interaction between genotype and environment; of course this does not exclude that environmental factors can modify the inherited genotype. The cancer phenotype is dependent on the interaction of one (monogenic inheritance) or more (polygenic inheritance) “cancergenes”, which may be dominant or recessive, with the surrounding conditions which may or may not favor the progression of the pre-malignant cells. As far as the polygenic model is concerned, the expression of the cancerphenotype may be understood as the probability to combine in a given cell, the expression of a given set of genes; due to the number of cancergenes, different combinations of genesets can be responsible for the (pre)-malignant status.
KeywordsCellulose Corn Trypsin Nylon Aflatoxin
Unable to display preview. Download preview PDF.
- 2.J. Bischop, Trends in oncogenesis. Trends in Genetics, 245 (1985)Google Scholar
- 16.M. Goyette, C. Petropoulos, P. Shank and N. Fausto, Regulated transcription of c-Ki-ras and c-myc during compensatory growth of rat liver. Mol, and cell. Biol. 4: 1493 (1984).Google Scholar
- 17.H. Godoy, D. Judah, IT. Arora, G. Neal, G. Jones, The effects of prolonged feeding with aflatoxin B1 on adult rat liver. Cancer Res. 36:2399(1976).Google Scholar
- 18.F. Gonzaler-Mujica, A. Mathias, Studies of nuclei separated by zonal centrifugation from liver of rats treated with thiocetamide. Biochem. J.132: 163 (1973).Google Scholar
- 24.H. Mori, T. Tanaka, S. Sugie, M. Takhahashi, G. Williams, DNA content of liver cell nuclei of N-2-fluorrenylacetamide -induced altered foci and neoplasms in rats and human hyperplastic foci, J. of Natl. Cancer. Inst. 69: 1277 (1982).Google Scholar
- 25.F.F. Becker, R.A. Fox, K.M. Klein, S.R. Wolman, Chromosome patterns in rat hepatocytes during N-2 fluorenylacetamide carcinogenesis. J. of Natl. Cancer Inst. 46:1261 (1971).Google Scholar
- 26.J.A. Styles, M. Kelly, C.R. Elcombe, A cytological comparison between regeneration, hyperplasia and early neoplasia in the rat liver. Carcinogenesis 8,3:391 (1987).Google Scholar
- 28.D. Corcos, N. Defer, M. Raymondjean, B. Paris, M. Corral, L. Tichonicky, J. Kruch, D. Glaise, A. Saulnier and C. Guguen-Guillaouza, Correlated increase of the expression of the c-ras genes in chemically induced hepatocarcinomas, Biochem. and Biophvs. Res. Comm. 122; 259 (1984).CrossRefGoogle Scholar
- 30.P. Jaswen, M. Goyette, P. Shank and N. Fausto, Expression of c-Ki-ras, c-Ha-ras and c-myc in specific cell types during hepatocarcinogenesis, Mol. and Cell. Biol., 5:780 (1985).Google Scholar