Abstract
The interior of a lipid bilayer is a medium of low dielectric constant and therefore represents an extremely high energy barrier for the passage of small ions such as Na+ or K+. The ion permeability of biological membranes depends, to a large extent, on the presence of specialized membrane constituents which provide energetically favourable pathways for ion transport through the apolar core of the membrane. The following chapter deals with the study of such ion transport mechanisms (carrier and channel mechanisms) using artificial lipid bilayer membranes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
References
A. PARSEGIAN, Nature (London), 221, 844 (1969).
B. NEUMCKE and P. LĂ„UGER, Biophys. J., 9, 1150 (1969).
S. McLAUGHLIN, Electrostatic Potentials at Membrane Solution Interfaces, in: Current Topics in Membrane and Transport, F. BRONNER and A KLEINZELLER (Editors), Academic Press, New York, (1977) Vol. 9, pp. 71–144.
P. MUELLER, D. O. RUDIN, H. T. TIEN and W. D. WESCOT, Nature (London), 194, 979 (1962).
T. HANAI, D.A. HAYDON and J. TAYLOR, Proc. Roy. Soc. Edinburgh Sect. A, 281, 377 (1964).
C. HUANG and T.E. THOMPSON, J. Mol. Biol., 13, 183 (1965).
M. MONTAL and P. MUELLER, Proc. Nat. Acad. Sci. USA, 69, 3561 (1972).
R. BENZ, O. FrĂ–Hlich, P. LAUGER and M. MONTAL, Biochim. Biophys. Acta, 394, 323 (1975).
H. SCHINDLER and J.P. ROSENBUSCH, Proc. Natl. Acad. Sci. USA, 75, 3751, (1978).
B. KETTERER, B. NEUMCKE and P. LĂ„UGER, J. Membr. Biol., 5, 225 (1971).
G. STARK, R. BENZ, B. KETTERER and P. LĂ„UGER, Biophys. J., 11, 981 (1971).
J.M. KUDIRKA, P.H. DAUM and C.G. ENKE, Anal. Chem., 44, 309 (1972).
M.P. BORISOVA, L.N. ERMISHKIN, F.A. LIBERMAN, A.Y. SILBERSTEIN and E.M. TROFIMOV, J. Membr. Biol., 18, 243 (1974).
C. GAVACH and R. SANDEAUX, Biochim. Biophys. Acta, 413, 33 (1975).
S.W. FELDBERG and G. KISSEL, J. Membr. Biol., 20, 269 (1975).
R. BENZ and P. LAUGER, J. Membr. Biol., 27, 171 (1976).
W. KNOLL and G. STARK, J. Membr. Biol., 37, 13 (1977).
W. BROCK, G. STARK and P.C. JORDAN, Biophys. Chem., 13, 329 (1981).
O.H. LEBLANC Jr., Biochim. Biophys. Acta, 193, 350 (1969).
L.J. BRUNER, J. Membr. Biol., 22, 125 (1975).
O.S. ANDERSEN and M. FUCHS, Biophys. J., 15, 795 (1975).
R. BENZ, P. LAUGER and K. JANKO, Biochim. Biophys. Acta, 455, 701 (1976).
P. LAUGER, R. BENZ, G. STARK, E. BAMBERG, P.C. JORDAN, A. FAHR and W. BROCK, Q. Rev. Biophys., 14, 513 (1981).
YU. A. OVCHINNIKOV, V.T. IVANOV and A.M. SKROB, Membrane-active complexones, Elsevier Scientific Publishing Company, Amsterdam, (1974).
R. BENZ and P. LAUGER, J. Membr. Biol., 27, 171 (1976).
P. LĂ„Uger, Science, 178, 24 (1972).
S.B. HLADKY and D.A. HAYDON, Biochim. Biophys. Acta, 274, 294 (1972).
D.W. URRY, Proc. Natl. Acad. Sci. USA, 68, 672 (1971).
E. BAMBERG, H. ALPES, H.–J. APELL, R. BENZ, K. JANKO, H. -A. KOLB, P. LAUGER and E. GROSS, FEBS Symposium No. 42, G. Semenza and E. Carafoli (Editors)), Springer Verlag, Berlin, (1977) pp. 179–201.
Further useful readings
S. B. HLADKY and D. A. HAYDON, Current Topics in Membrane and Transport, 21, 327 (1984).
A. FINKELSTEIN and O. S. ANDERSEN, J. Membr. Biol., 59, 155 (1981).
W. BURGERMEISTER and R. WINKLER-OSWATITSCH, Top. Curr. Chem. 69, 91 (1977).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Läuger, P. (1987). Charge Transport Across Lipid Bilayer Membranes: Lipophilic Ions, Ion Carriers and Channels. In: Milazzo, G., Blank, M. (eds) Bioelectrochemistry II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0951-2_9
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0951-2_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8261-7
Online ISBN: 978-1-4613-0951-2
eBook Packages: Springer Book Archive