Charge Transport Across Lipid Bilayer Membranes: Lipophilic Ions, Ion Carriers and Channels

  • P. Läuger


The interior of a lipid bilayer is a medium of low dielectric constant and therefore represents an extremely high energy barrier for the passage of small ions such as Na+ or K+. The ion permeability of biological membranes depends, to a large extent, on the presence of specialized membrane constituents which provide energetically favourable pathways for ion transport through the apolar core of the membrane. The following chapter deals with the study of such ion transport mechanisms (carrier and channel mechanisms) using artificial lipid bilayer membranes.


Bilayer Membrane Lipid Bilayer Membrane Dipolar Potential Interfacial Potential Planar Bilayer 
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  1. [1]
    A. PARSEGIAN, Nature (London), 221, 844 (1969).PubMedCrossRefGoogle Scholar
  2. [2]
    B. NEUMCKE and P. LÄUGER, Biophys. J., 9, 1150 (1969).CrossRefGoogle Scholar
  3. [3]
    S. McLAUGHLIN, Electrostatic Potentials at Membrane Solution Interfaces, in: Current Topics in Membrane and Transport, F. BRONNER and A KLEINZELLER (Editors), Academic Press, New York, (1977) Vol. 9, pp. 71–144.CrossRefGoogle Scholar
  4. [4]
    P. MUELLER, D. O. RUDIN, H. T. TIEN and W. D. WESCOT, Nature (London), 194, 979 (1962).PubMedCrossRefGoogle Scholar
  5. [5]
    T. HANAI, D.A. HAYDON and J. TAYLOR, Proc. Roy. Soc. Edinburgh Sect. A, 281, 377 (1964).Google Scholar
  6. [6]
    C. HUANG and T.E. THOMPSON, J. Mol. Biol., 13, 183 (1965).PubMedCrossRefGoogle Scholar
  7. [7]
    M. MONTAL and P. MUELLER, Proc. Nat. Acad. Sci. USA, 69, 3561 (1972).PubMedCrossRefGoogle Scholar
  8. [8]
    R. BENZ, O. FrÖHlich, P. LAUGER and M. MONTAL, Biochim. Biophys. Acta, 394, 323 (1975).PubMedCrossRefGoogle Scholar
  9. [9]
    H. SCHINDLER and J.P. ROSENBUSCH, Proc. Natl. Acad. Sci. USA, 75, 3751, (1978).PubMedCrossRefGoogle Scholar
  10. [10]
    B. KETTERER, B. NEUMCKE and P. LÄUGER, J. Membr. Biol., 5, 225 (1971).CrossRefGoogle Scholar
  11. [11]
    G. STARK, R. BENZ, B. KETTERER and P. LÄUGER, Biophys. J., 11, 981 (1971).PubMedCrossRefGoogle Scholar
  12. [12]
    J.M. KUDIRKA, P.H. DAUM and C.G. ENKE, Anal. Chem., 44, 309 (1972).CrossRefGoogle Scholar
  13. [13]
    M.P. BORISOVA, L.N. ERMISHKIN, F.A. LIBERMAN, A.Y. SILBERSTEIN and E.M. TROFIMOV, J. Membr. Biol., 18, 243 (1974).PubMedCrossRefGoogle Scholar
  14. [14]
    C. GAVACH and R. SANDEAUX, Biochim. Biophys. Acta, 413, 33 (1975).PubMedCrossRefGoogle Scholar
  15. [15]
    S.W. FELDBERG and G. KISSEL, J. Membr. Biol., 20, 269 (1975).PubMedCrossRefGoogle Scholar
  16. [16]
    R. BENZ and P. LAUGER, J. Membr. Biol., 27, 171 (1976).PubMedCrossRefGoogle Scholar
  17. [17]
    W. KNOLL and G. STARK, J. Membr. Biol., 37, 13 (1977).PubMedCrossRefGoogle Scholar
  18. 118]
    W. BROCK, G. STARK and P.C. JORDAN, Biophys. Chem., 13, 329 (1981).PubMedCrossRefGoogle Scholar
  19. [19]
    O.H. LEBLANC Jr., Biochim. Biophys. Acta, 193, 350 (1969).CrossRefGoogle Scholar
  20. [20]
    L.J. BRUNER, J. Membr. Biol., 22, 125 (1975).PubMedCrossRefGoogle Scholar
  21. [21]
    O.S. ANDERSEN and M. FUCHS, Biophys. J., 15, 795 (1975).PubMedCrossRefGoogle Scholar
  22. [22]
    R. BENZ, P. LAUGER and K. JANKO, Biochim. Biophys. Acta, 455, 701 (1976).PubMedCrossRefGoogle Scholar
  23. [23]
    P. LAUGER, R. BENZ, G. STARK, E. BAMBERG, P.C. JORDAN, A. FAHR and W. BROCK, Q. Rev. Biophys., 14, 513 (1981).PubMedCrossRefGoogle Scholar
  24. [24]
    YU. A. OVCHINNIKOV, V.T. IVANOV and A.M. SKROB, Membrane-active complexones, Elsevier Scientific Publishing Company, Amsterdam, (1974).Google Scholar
  25. [25]
    R. BENZ and P. LAUGER, J. Membr. Biol., 27, 171 (1976).PubMedCrossRefGoogle Scholar
  26. [26]
    P. LÄUger, Science, 178, 24 (1972).PubMedCrossRefGoogle Scholar
  27. [27]
    S.B. HLADKY and D.A. HAYDON, Biochim. Biophys. Acta, 274, 294 (1972).PubMedCrossRefGoogle Scholar
  28. [28]
    D.W. URRY, Proc. Natl. Acad. Sci. USA, 68, 672 (1971).PubMedCrossRefGoogle Scholar
  29. [29]
    E. BAMBERG, H. ALPES, H.–J. APELL, R. BENZ, K. JANKO, H. -A. KOLB, P. LAUGER and E. GROSS, FEBS Symposium No. 42, G. Semenza and E. Carafoli (Editors)), Springer Verlag, Berlin, (1977) pp. 179–201.Google Scholar

Further useful readings

  1. S. B. HLADKY and D. A. HAYDON, Current Topics in Membrane and Transport, 21, 327 (1984).Google Scholar
  2. A. FINKELSTEIN and O. S. ANDERSEN, J. Membr. Biol., 59, 155 (1981).PubMedCrossRefGoogle Scholar
  3. W. BURGERMEISTER and R. WINKLER-OSWATITSCH, Top. Curr. Chem. 69, 91 (1977).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. Läuger
    • 1
  1. 1.Department of BiologyUniversity of KonstanzKonstanzGermany

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