Autoantibodies of IgM and IgG Class Against Eye Muscle Antigens in Patients with Graves Ophthalmopathy
The presence of autoantibodies /aab/ reacting with microsomal membrane1 or plasma membrane /AEMA/2 eye muscle antigens have been recently reported in Graves ophthalmophathy /GO/.The significance of humoral mediated immunity in GO was further supported by studies in which correlation between presence and development of ophthalmopathy and titer of anti membrane autoantibodies were established.3,4
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- 3.J.Nauman,M, Faryna, A, Gardas, Humoral immunity in Graves ophthalmopathy in “The thyroid and Autoimmunity” H.A. Drexhage, W.M. Wiersinga,ed. Excerpta Medica, Amsterdam /1986/.Google Scholar
- 5.U. Bemetz, R. Moncayo, W. Scherbaim, H. Frisch, K. Badenhoop, G. Hool, H. Schleussener, E.F. Pfeiffer, Detection of IgG and IgM antibodies directed aqainst eyeand peripheral muscle preparations in juvenile and adult patients with Graves disease and in patients with hyperhyroidism : “The thyroid and autoimmunity”, H.A. Drexhage, W.M. Wiersinga,ed., Excerpta Medica, Amsterdam /1986/.Google Scholar