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Autoantibodies of IgM and IgG Class Against Eye Muscle Antigens in Patients with Graves Ophthalmopathy

  • Grazyna Adler
  • Martha Faryna
  • Aleksandra Lewartowska
  • Janusz Nauman
  • Andrzej Gardas
  • Hanna Domek

Abstract

The presence of autoantibodies /aab/ reacting with microsomal membrane1 or plasma membrane /AEMA/2 eye muscle antigens have been recently reported in Graves ophthalmophathy /GO/.The significance of humoral mediated immunity in GO was further supported by studies in which correlation between presence and development of ophthalmopathy and titer of anti membrane autoantibodies were established.3,4

Keywords

Grave Disease Grave Ophthalmopathy Nonnal Serum Humoral Mediate Immunity Sore Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P. Kendall-Taylor, S. Atkinson, M. Holccme, A specific IgG in Graves ophthalmopatha and its relation to retro-orbital and thyroid autoimmunity, Br. Med. J. 288:1183 /1984/.CrossRefGoogle Scholar
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    M. Faryna, J. Nauman, A. Gardas, Estimation of autoantibodies against human eye muscle plasma membranes in Graves ophthalmopathy,Br.Med. J. 290:191/1985/CrossRefGoogle Scholar
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    J.Nauman,M, Faryna, A, Gardas, Humoral immunity in Graves ophthalmopathy in “The thyroid and Autoimmunity” H.A. Drexhage, W.M. Wiersinga,ed. Excerpta Medica, Amsterdam /1986/.Google Scholar
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    S. Atkinson, M. Holccme, P. Kendall-Taylor, Ophthalmopathy irrmunoglobulin in patients with Graves ophthalmopathy, Lancet ii:374 /1984/.CrossRefGoogle Scholar
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    U. Bemetz, R. Moncayo, W. Scherbaim, H. Frisch, K. Badenhoop, G. Hool, H. Schleussener, E.F. Pfeiffer, Detection of IgG and IgM antibodies directed aqainst eyeand peripheral muscle preparations in juvenile and adult patients with Graves disease and in patients with hyperhyroidism : “The thyroid and autoimmunity”, H.A. Drexhage, W.M. Wiersinga,ed., Excerpta Medica, Amsterdam /1986/.Google Scholar

Copyright information

© Plenum Press, New York 1997

Authors and Affiliations

  • Grazyna Adler
    • 1
  • Martha Faryna
    • 1
  • Aleksandra Lewartowska
    • 1
  • Janusz Nauman
    • 1
  • Andrzej Gardas
    • 1
  • Hanna Domek
    • 1
  1. 1.Department of BiochemistryMedical Center of Postgraduate EducationWarsawPoland

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