Autoantibodies of IgM and IgG Class Against Eye Muscle Antigens in Patients with Graves Ophthalmopathy
The presence of autoantibodies /aab/ reacting with microsomal membrane1 or plasma membrane /AEMA/2 eye muscle antigens have been recently reported in Graves ophthalmophathy /GO/.The significance of humoral mediated immunity in GO was further supported by studies in which correlation between presence and development of ophthalmopathy and titer of anti membrane autoantibodies were established.3,4
KeywordsGrave Disease Grave Ophthalmopathy Nonnal Serum Humoral Mediate Immunity Sore Case
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- 3.J.Nauman,M, Faryna, A, Gardas, Humoral immunity in Graves ophthalmopathy in “The thyroid and Autoimmunity” H.A. Drexhage, W.M. Wiersinga,ed. Excerpta Medica, Amsterdam /1986/.Google Scholar
- 5.U. Bemetz, R. Moncayo, W. Scherbaim, H. Frisch, K. Badenhoop, G. Hool, H. Schleussener, E.F. Pfeiffer, Detection of IgG and IgM antibodies directed aqainst eyeand peripheral muscle preparations in juvenile and adult patients with Graves disease and in patients with hyperhyroidism : “The thyroid and autoimmunity”, H.A. Drexhage, W.M. Wiersinga,ed., Excerpta Medica, Amsterdam /1986/.Google Scholar