Inappropriate HLA Class II Expression in a Wide Variety of Thyroid Diseases
Thyroid follicular cells from glands afflicted by autoimmune disease often express HLA Class II molecules (1–5). The mechanism(s) by which this ‘inappropriate’ Class II expression arises in vivo and whether it is restricted to thyroid autoimmune disease remains uncertain. To gain insights into this phenomenon we have studied Class II expression in all the thyrodectomy specimens collected during one year from a major teaching hospital (Hospital General Valle de Hebron, Universidad Autonoma de Barcelona, Barcelona, Spain). Class I and Class II expression were correlated with the clinical diagnosis, with lymphocytic infiltration and with thyroid autoantibodies.
KeywordsAdenoma Paraffin Trias Thyrotoxicosis Thyroiditis
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- 2.R. Jansson, A. Karlsson, U. Forsum, Intrathyroid HLA-DR expression and T lymphocyte phenotypes in Graves’ thyrotoxicosis, Hashimoto’s thyroiditis and nodular colloid goitre, Clin exp Immunol, 58: 264–272 (1985).Google Scholar
- 3.G. Aichinger, H. Fill, G. Wick, In situ immune complexes, lymphocyte subpopulations and HLA-DR positive epithelial cells in Hashimoto thyroditis, Lab invest, 52: 132-140.Google Scholar