Inappropriate HLA Class II Expression in a Wide Variety of Thyroid Diseases
Thyroid follicular cells from glands afflicted by autoimmune disease often express HLA Class II molecules (1–5). The mechanism(s) by which this ‘inappropriate’ Class II expression arises in vivo and whether it is restricted to thyroid autoimmune disease remains uncertain. To gain insights into this phenomenon we have studied Class II expression in all the thyrodectomy specimens collected during one year from a major teaching hospital (Hospital General Valle de Hebron, Universidad Autonoma de Barcelona, Barcelona, Spain). Class I and Class II expression were correlated with the clinical diagnosis, with lymphocytic infiltration and with thyroid autoantibodies.
KeywordsLymphocytic Infiltration Thyroid Autoimmune Disease Laryngeal Carcinoma Follicular Adenoma Thyroid Autoantibody
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