Thyroid Autoimmunity as a Major Cause for Congenital Hypothyroidism
A causal relationship between maternal autoimmune thyroid disease and congenital hypothyroidism (CH) of the infant has been suggested as early as 1960.1,2 Subsequent observations in single families with maternal autoimmune thyroid disease and repeated occurrence of congenital hypothyroidism in the children were reported.3 With the establishment of a KH-screening program for CH a large number of newborns with CH were tested for microsomal (Mab) and thyroglobulin (Tab) antibodies in the neonatal period, which did not show an increased frequency of these antibodies in affected children compared to normal newborns.4 However, since during the last years, other types of antibodies than Mab and Tab could be measured in those newborns, increasing evidence for supporting the hypothesis of maternal autoimmune thyroid disease as a pathogenetic mechanism of CH was raised.5,6 Therefore we determined the frequency of different types of thyroid antibodies in newborns with CH and their mothers in correlation to the type of congenital hypothyroidism.
KeywordsCongenital Hypothyroidism Thyroid Antibody Cytotoxic Antibody Normal Newborn Mass Screening Program
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