Abstract
INTRODUCTION It has recently been shown that the pathogenically important TSH receptor antibodies found in Graves’ disease are mainly synthesised by lymphocytes closely associated with thyroid follicles.1It has also been shown that these antibodies are almost exclusively restricted to the K light chain type.2 In this study we have used an immunoperoxidase technique to analyse, in situ, the distribution of the λ light chain isotypes of plasma cells found within Graves’1 disease thyroids.
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S.M. McLauchlan, C.A.S. Pegg, M.C. Atherton, S.L. Middleton, F. Clark and B. Rees Smith, TSH receptor antibody synthesis by thyroid lymphocytes, Clin. Endocrinol. 24:223 (1986).
J. Knight, P. Laine, A. Knight, D. Adams and N. Ling, Thyroid stimulating autoantibodies usually contain only A -light chains: evidence for the “forbidden clone” theory, J. Clin. Endocrinol. Metab. 62:342 (1986).
B. Jasani, R.E. Edwards, N.D. Thomas and A.R. Gibbs, The use of vimentin antibodies in the diagnosis of malignant mesothelioma, Virchows Arch. (Pathol. Anat.) 406:441 (1985).
C. Smith and B. Jasani, Immunohistochemical definition of lymphocyte subpopulations in autoimmune thyroiditis, J. Path. 143:297A (1984).
B. Jasani, C. Smith and E.D. Williams, A high predominance of 0KT8+ and activated leu 3a cells in the scattered lymphocyte population of the Graves disease thyroid, J. Endocrinol. 104 (Supplement), 96:160A (1985).
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© 1987 Plenum Press, New York
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Smith, C.A., Jasani, B., Dillwyn Williams, E. (1987). λ Light Chain Restriction in the Diffuse Thyroid Lymphoid Infiltrate in Untreated Graves’disease. In: Pinchera, A., Ingbar, S.H., McKenzie, J.M., Fenzi, G.F. (eds) Thyroid Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0945-1_49
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DOI: https://doi.org/10.1007/978-1-4613-0945-1_49
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8258-7
Online ISBN: 978-1-4613-0945-1
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