Lymphokine Production and Functional Activities of T Cell Clones From Thyroid Gland of Hashimoto’s Thyroiditis
Many investigations have been directed to elucidate the possible patogenethical role of T cells in autoimmune thyroid diseases, namely Hashimoto’s thyroiditis (HT) and Graves’ diseases (GD). Phenotypic and functional analysis of T cells at the clonal level, using high-efficiency cloning techniques (1), proved to be the most reliable method for characterizing T cell functional repertoire at the level of the target organ. We thus employed such a technique to study T cells derived frcm thyroid infiltrates (and for ccmparizon, peripheral blood) of patients with HT or GD. The results obtained demonstrated major differences between the two disease, as far as both lymphokine (namely, ɣ -interferon ɣIFN) production and cytolytic capabilities are concerned.
KeywordsCell Clone 51cr Release Assay Thyroid Epithelial Cell Clonal Level P815 Cell Line
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