Lymphokine Production and Functional Activities of T Cell Clones From Thyroid Gland of Hashimoto’s Thyroiditis

  • M. Bagnasco
  • S. Ferrini
  • D. Venuti
  • I. Prigione
  • G. Giordano
  • G. W. Canonica

Abstract

Many investigations have been directed to elucidate the possible patogenethical role of T cells in autoimmune thyroid diseases, namely Hashimoto’s thyroiditis (HT) and Graves’ diseases (GD). Phenotypic and functional analysis of T cells at the clonal level, using high-efficiency cloning techniques (1), proved to be the most reliable method for characterizing T cell functional repertoire at the level of the target organ. We thus employed such a technique to study T cells derived frcm thyroid infiltrates (and for ccmparizon, peripheral blood) of patients with HT or GD. The results obtained demonstrated major differences between the two disease, as far as both lymphokine (namely, ɣ -interferon ɣIFN) production and cytolytic capabilities are concerned.

Keywords

Interferon Thyroiditis 

References

  1. 1).
    Moretta, A. et al. J. Exp. Med., 1983, 157,743.PubMedCrossRefGoogle Scholar
  2. 2).
    Bagnasco et al. , Int. Arch. Allergy Appl. Immunol. 1986 in pressGoogle Scholar
  3. 3).
    Taswell C., J. Immunol. 1981, 126, 1614.PubMedGoogle Scholar
  4. 4).
    Todd I. et al. clin. Exp. Immunol. 1985, 61, 265PubMedGoogle Scholar
  5. 5).
    Canonica G.W. et al. , Clin. Immunol. Immunopatilol., 1985, 36, 40.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Bagnasco
    • 1
  • S. Ferrini
    • 1
  • D. Venuti
    • 1
  • I. Prigione
    • 1
  • G. Giordano
    • 1
  • G. W. Canonica
    • 1
  1. 1.I.S.T.-Endocrinologia & Semeiotica Medica III (I.S.M.I.)Genoa UniversityGenoaItaly

Personalised recommendations