Thyroid and Renal Amyloidosis in Thyroglobulin Immunized Rabbits

  • B. N. Premachandra
  • H. T. Blumenthal


A variety of forms of immune complex nephritis have been reported in human thyroid disorders of immune origin as well as in animals with an induced lymphocytic thyroiditis 2. Several types of amyloid also represent expressions of immune system disorders. However, there are no reports of thyroid or renal amyloid associated with human thyroid disorders of immune origin, or in thyroglobulin (Tg) immunized animals. In recent investigations in animals with induced lymphocytic thyroiditis we observed amyloid lesions in thyroid and kidney.


Potassium Permanganate Renal Amyloidosis Lymphocytic Thyroiditis Immunize Rabbit Immune System Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Jordan, S.C., Buckingham, B., Sakai, R. and Olson, D. Studies of immune-complex glomerulonephritis mediated by human thyroglobulin. New Eng. J. Med., 304:1212 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    Germuth, F.G., Rodriguez, E., Siddiqui, S.Y., Lorelle, C.A., McGee, S., Milano, L.L., and Wise, O. Immune complex disease. VII. Experimental mesangiopathic glomerulonephritis produced by chronic immunization with thyroglobulin. Lab. Invest., 38:404 (1978).PubMedGoogle Scholar
  3. 3.
    Wright, J.R., Calkins, E. and Humphrey, R.L. Potassium permanganate reaction in amyloidosis: A histologic method to assist in differentiating forms of this disease. Lab. Invest., 36:274 (1977).PubMedGoogle Scholar
  4. 4.
    Casas, C.B. and Buso, R. Amyloidosis in C3H mice treated with goitrogens. Amer. J. Path., 45:645 (1964).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • B. N. Premachandra
    • 1
  • H. T. Blumenthal
    • 1
  1. 1.Veterans Administration Medical CenterWashington UniversityMissouriUSA

Personalised recommendations