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Dietary Retinoids and the Chemoprevention of Mammary Gland Tumorigenesis

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Book cover Cellular and Molecular Biology of Mammary Cancer

Abstract

Over the years, the thrust of cancer therapy has been the destruction of malignant cells; comparatively little effort has been directed toward modifying the behavior of malignant cells toward normalcy. In recent years, considerable interest in the use of dietary retinoids (vitamin A and its naturally occurring and synthetic analogues) as potential mediators of this process has come to the fore. To date, the “chemopreventive” effects of dietary retinoids have been demonstrated in a variety of experimental tumor models; tumorigenesis of the bladder, cervix, colon, forestomach, integument, liver, lung, pancreas, vagina and mammary glands has been suppressed by the feeding of pharmacological levels of natural and synthetic retinoids. The purpose of this communication is to provide a succinct review of the pertinent information that has emerged in recent years documenting the use of retinoids in the chemoprevention of mammary tumorigenesis in experimental animals. More specifically, this review will examine the chemopreventive effects of dietary retinoids in the development of mammary tumors in rats and mice and lastly will focus on potential mechanisms by which these compounds may suppress tumorigenesis.

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Authors and Affiliations

  1. Department of Anatomy, Michigan State University, East Lansing, Michigan, 48824, USA

    Clifford W. Welsch

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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Daniel Medina

  2. National Cancer Institute, Bethesda, Maryland, USA

    William Kidwell  & Elizabeth Anderson  & 

  3. Michigan Cancer Foundation, Detroit, Michigan, USA

    Gloria Heppner

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Welsch, C.W. (1987). Dietary Retinoids and the Chemoprevention of Mammary Gland Tumorigenesis. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_27

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  • DOI: https://doi.org/10.1007/978-1-4613-0943-7_27

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