Overt and Cryptic Functions of the Mouse Mammary Tumor Virus Long Terminal Repeat DNA Sequence

  • Gilbert H. Smith
Chapter

Abstract

As for other retroviruses, the synthesis of mouse mammary tumor virus (MMTV) proviral DNA by reverse transcriptase is a complex and indispensable process for establishment of a vegetative viral life cycle. MMTV contains a single-stranded genomic RNA with a sedimentation coefficient of between 60–70S and a molecular mass of 6.45 x 106daltons, (1,2). This virion-contained RNA consists of two subunits (35S), each with molecular masses of 2.93 x 106daltons. The 3’ terminus of MMTV genomic RNA is polyadenylated, and the 5’ terminus most likely carries the CAP structure 5’m7GpppG which is present in other retroviral genomic RNAs (3). Like other retroviruses, MMTV genomic RNA is copied into proviral dsDNA by a virally encoded reverse transcriptase. The proviral DNA is eventually integrated into the host cell chromosomal DNA in an apparently random fashion (4,5)

Keywords

Lymphoma Estrogenic Lactate Corticosteroid Adenosine 

Abbreviations

MMTV

mouse mammary tumor virus

LTR

long terminal repeat

orf

open reading frame

DNA

deoxyribonucleic acid

RNA

ribonucleic acid

mRNa

messenger RNA

Dex

dexamethasone

ADP

adenosine diphosphate

HRE

hormone responsive element

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Gilbert H. Smith
    • 1
  1. 1.Division of Cancer Biology and DiagnosisNational Cancer Institute National Institutes of HealthUSA

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