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Hormonal Control of Mouse Mammary Tumor Virus Transcription

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Cellular and Molecular Biology of Mammary Cancer

Abstract

Mouse mammary tumor virus (MMTV) is a RNA-containing tumor virus that causes mammary cancer in mice. MMTV has a life cycle similar to that of other characterized retroviruses, yet MMTV is not completely analogous to the other viruses (1). Some of its unique features have attracted considerable attention in the past few years. First, MMTV transcription is regulated by glucocorticoid hormones. The isolation of MMTV proviruses by gene cloning followed by their transfer into cultured cells has allowed major insights into the mechanism of steroid hormone action (2,3). Second, MMTV belongs to the group of retroviruses that do not carry an oncogene. Recent results suggest that the transformation of mammary gland cells is related to the integration site of the MMTV viral DNA in the host genome. Thus, MMTV most likely transforms cells via insertional mutagenesis (4,5). In this article we will limit our discussion to experiments concerning the hormonal control of MMTV transcription. We will show that glucocorticoid as well as gonadal steroid hormones can enhance MMTV transcription. The role which MMTV plays in mammary tumor formation will be described in other chapters in this book

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Author information

Authors and Affiliations

  1. Ludwig Institute for Cancer Research Inselspital, CH-3010, Bern, Switzerland

    N. E. Hynes & B. Groner

  2. Institute for Genetics Kernforschungszentrum Karlsruhe, D-7500, Karlsruhe, Germany

    A. Cato & H. Ponta

Authors
  1. N. E. Hynes
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  2. B. Groner
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  3. A. Cato
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  4. H. Ponta
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Daniel Medina

  2. National Cancer Institute, Bethesda, Maryland, USA

    William Kidwell  & Elizabeth Anderson  & 

  3. Michigan Cancer Foundation, Detroit, Michigan, USA

    Gloria Heppner

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© 1987 Plenum Press, New York

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Hynes, N.E., Groner, B., Cato, A., Ponta, H. (1987). Hormonal Control of Mouse Mammary Tumor Virus Transcription. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_18

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  • DOI: https://doi.org/10.1007/978-1-4613-0943-7_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-42761-9

  • Online ISBN: 978-1-4613-0943-7

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