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Neural System Imbalances and the Consequence of Large Brain Injuries

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Abstract

It is reported that while addressing a group of graduating college students, Dr. Seuss related some advice from Uncle Terwillinger concerning the art of eating popovers. Dr. Seuss noted that it was Uncle Terwillinger’s suggestion that “to eat these things, you must exercise great care. You may swallow down what is solid, . . . but you must spit out what is air!” Given the range of beliefs concerning the consequences of brain injury, it appears that students of recovery of function may also need to heed Uncle Terwillinger’s sage counsel. For example, at one extreme there are those who believe that the organization of the nervous system is quite stable, so that the behavioral consequences of neural injury are determined by whether or not what is spared can function normally. At the other extreme there are those who believe that the nervous system is quite plastic, so that the behavioral consequences of neural injury depend on whether or not neural centers will reorganize and function vicariously. There should be little surprise that such extreme positions have set the boundaries of fertile soil in which considerable debate and controversy can germinate and be nurtured. And understandably so, since the consequences of brain injury will necessarily define the mechanisms of recovery of function as well as how we should best proceed to understand and ultimately facilitate these mechanisms.

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References

  • Bartus, R. T., Flicker, C., Dean, R. L., Pontecorvo, M., Figueredo, J. C., and Fisher, S. K., 1985, Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies, Pharmacol. Biochem. Behav. 23:125–135.

    Article  PubMed  CAS  Google Scholar 

  • Bartus, R. T., Pontecorvo, M. J., Flicker, C., Dean, R. L., and Figueiredo, J. C, 1986, Behavioral recovery following bilateral lesions of the nucleus basalis does not occur spontaneously, Pharmacol Biochem. Behav. 24:1287–1292.

    Article  PubMed  CAS  Google Scholar 

  • Baumann, T. P., and Spear, P. D., 1977, Role of lateral suprasylvian visual area in behavioral recovery from effects of visual cortex damage in cats, Brain Res. 138:45–468.

    Article  Google Scholar 

  • Cannon, W. B., and Rosenblueth, A., 1949, The Supersensitivity of Denervated Structures: A Law of Denervation, Macmillan, New York.

    Google Scholar 

  • Chappell, E. T., and LeVere, T. E., 1988, Recovery of function after brain damage: The chronic consequences of large neocortical injuries, Behav. Neuroscience (In press).

    Google Scholar 

  • Cooper, R. M., Freeman, I., and Pinel, J. P. J., 1967, Absolute threshold of vision in the rat after removal of striate cortex, J. Comp. Physiol. Psychol. 64:36–39.

    Article  PubMed  CAS  Google Scholar 

  • Cotman, C. W., Nieto-Sampedro, M., and Harris, E. W., 1981, Synapse replacement in the nervous system of adult vertebrates, Physiol. Rev. 61:684–784.

    PubMed  CAS  Google Scholar 

  • Cotman, C. W., and Nieto-Sampedro, M., 1982, Brain function, synapse renewal, and plasticity, Annu. Rev. Psychol. 33:371–401.

    Article  PubMed  CAS  Google Scholar 

  • Davis, N., and LeVere, T. E., 1982, Recovery of function after brain damage: The question of individual behaviors or functionality, Exp. Neurol. 75:68–78.

    Article  PubMed  CAS  Google Scholar 

  • Exner, S., 1885, Notiz zu der Frage von der Faservertheilung mehrerer Nerven in einem Muskel, Pflugers Arch. 36:572–576.

    Article  Google Scholar 

  • Finger, S., and Stein, D. G., 1982, Brain Damage and Recovery, Academic Press, New York.

    Google Scholar 

  • Gillespie, L. A., and Cooper, R. A., 1973, Visual cortical lesions in the rat and a conditioned emotional response, J. Comp. Physiol. Psychol. 83:76–91.

    Article  PubMed  CAS  Google Scholar 

  • Goodale, M. A., 1973, Cortico-tectal and intertectal modulation of visual responses in the rat’s superior colliculus, Exp. Neurol. 17:75–86.

    CAS  Google Scholar 

  • Goodman, D. C., and Horel, J., 1966, Sprouting of optic tract projections in the brain stem of the rat, J. Comp. Neurol. 127:71–88.

    Article  PubMed  CAS  Google Scholar 

  • Guth, L., 1974, Axonal regeneration and functional plasticity in the central nervous system, Exp. Neurol. 45:606–654.

    Article  PubMed  CAS  Google Scholar 

  • Guth, L., and Bernstein, J. J., 1961, Selectivity in the re-establishment of synapses in the superior cervical sympathetic ganglion of the cat, Exp. Neurol. 4:59–69.

    Article  PubMed  CAS  Google Scholar 

  • Harrell, L. E., Barlow, T. S., and Davis, J. N., 1983, Sympathetic sprouting and recovery of spatial behavior, Exp. Neurol. 82:379–390.

    Article  PubMed  CAS  Google Scholar 

  • Kamin, L. J., 1967, Attention-like processes in classical conditioning, in: Miami Symposium of the Prediction of Behavior: Adversive Stimulation (M. R. Jones, ed.), University of Miami Press, Miami, pp. 9–31.

    Google Scholar 

  • Kamin, L. J., 1969, Predictability, surprise, attention and conditioning, in: Punishment and Aversive Behavior (B. A. Campbell and R. M. Church, eds.), pp. 279–296, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Kozlowski, M. R., and Marshall, J. F., 1981, Plasticity of neostriatal metabolic activity and recovery from nigrostriatal injury, Exp. Neurol. 74:318–323.

    Article  PubMed  CAS  Google Scholar 

  • Lashley, K. S.. 1924, Studies of cerebral function in learning: V. The retention of motor habits after destruction of the so-called motor areas in primates, Arch. Neurol. Psychiatry 12:249–276.

    Google Scholar 

  • Lashley, K. S., 1930, The mechanism of vision: II. The influence of cerebral lesions upon the threshold of discrimination for brightness in the rat, J. Gen. Psychol. 37:461–480.

    Google Scholar 

  • Lashley, K. S., 1933, Integrative functions of the cerebral cortex, Psychol. Rev. 13:1–42.

    Google Scholar 

  • Lavond, D., Hata, M. G., Gray, T. S., Geckler, C. L., Meyer, P. M., and Meyer, D. R., 1978, Visual form perception is a function of the visual cortex, Physiol. Psychol. 6:471–477.

    Google Scholar 

  • LeVere, T. E., 1975, Neural stability, sparing, and behavioral recovery following brain damage, Psychol. Rev. 82:344–358.

    Article  PubMed  CAS  Google Scholar 

  • LeVere, T. E., 1980, Recovery of function after brain damage: A theory of the behavioral deficit, Physiol. Psychol. 8:297–308.

    Google Scholar 

  • Levere, N. D., and LeVere, T. E., 1982, Recovery of function after brain damage: Support for the compensation theory of the behavioral deficit, Physiol. Psychol. 10:165–174.

    Google Scholar 

  • LeVere, T. E., and Mills, J., 1977, Residual differential brightness thresholds following removal of visual neocortex in rats. Physiol. Psychol. 5:490–496.

    Google Scholar 

  • Lezak, M. D., 1983, Neuropsychological Assessment, Oxford University Press, New York.

    Google Scholar 

  • Liu, C.-N., and Chambers, W. W., 1958, Intraspinal sprouting of dorsal root axons, Arch. Neurol. Psychiatry 79:46–61.

    CAS  Google Scholar 

  • Marshall, J. R., 1979, Somatosensory inattention after dopamine-depleting intracerebral 6-OHDA injection: Spontaneous recovery and pharmacological control. Brain Res. 177:311–324.

    Article  PubMed  CAS  Google Scholar 

  • McCough, G. P., Austin, G. M., Liu, C.-N., and Lui, C. Y., 1958, Sprouting as a cause of spasticity, J. Neurophysiol. 21:205–216.

    Google Scholar 

  • Meyer, P. M., Horel, J. A., and Meyer, D. R., 1963, Effects of dl-amphetamine upon placing responses in neodecorticate cats, J. Comp. Physiol. Psychol. 56:402–404.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J. R., 1984, Brain function: Neural adaptations and recovery from injury, Annu. Rev. Psychol. 35:277–308.

    Article  PubMed  CAS  Google Scholar 

  • Miller, E., 1984, Recovery and Management of Neuropsychological Impairments, John Wiley, New York.

    Google Scholar 

  • Murray, C. L., and Fibiger, H. C, 1986, Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis, Behav. Neurosci. 100:23–32.

    Article  PubMed  CAS  Google Scholar 

  • Murray, J. G., and Thompson, J. W., 1957, The occurrence and function of collateral sprouting in the sympathetic nervous system of the cat, J. Physiol. (Lond.) 135:133–162.

    CAS  Google Scholar 

  • Nonneman, A. J., and Warren, J. M., 1977, Two-cue learning by brain damaged cats, Physiol. Psychol. 5:397–402.

    Google Scholar 

  • Raisman, G., 1969, Neuronal plasticity in the septal nuclei of the adult brain, Brain Res. 14:25–48.

    Article  PubMed  CAS  Google Scholar 

  • Spear, P. D., and Baumann, T. P., 1979, Neurophysiological mechanisms of recovery from visual cortex damage in cats: Properties of lateral suprasylvian visual area neurons following behavioral recovery, Exp. Brain Res. 35:177–192.

    Article  PubMed  CAS  Google Scholar 

  • Sprague, J. M., 1966, Interaction of cortex and superior colliculus in mediation of visually guided behavior in the cat, Science 153:1544–1547.

    Article  PubMed  CAS  Google Scholar 

  • Squire, L. R., and Cohen, N. J., 1984, Human memory and amnesia, in: Neurobiology of Learning and Memory (G. Lynch, J. L. McGaugh, and N. M. Weinberger, eds.), pp. 3–64, Guilford Press, New York.

    Google Scholar 

  • Trendelenburg, U., 1963, Supersensitivity and subsensitivity to sympamomimetic amines, Pharmacol. Rev. 15:225–276.

    PubMed  CAS  Google Scholar 

  • Weddle, G., Guttmann, L., and Gutman, E., 1941, The local extension of nerve fibers into denervated areas of skin, J. Neurol. Psychiatry 4:206–225.

    Article  Google Scholar 

  • Wood, C. C., Spear, P. D., and Braun, J. J., 1973, Direction-specific deficits in horizontal optokinetic nystagmus following removal of visual cortex in cat, J. Comp. Physiol. Psychol. 60:231–237.

    CAS  Google Scholar 

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© 1988 Plenum Press, New York

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LeVere, T.E. (1988). Neural System Imbalances and the Consequence of Large Brain Injuries. In: Finger, S., Levere, T.E., Almli, C.R., Stein, D.G. (eds) Brain Injury and Recovery. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0941-3_2

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  • DOI: https://doi.org/10.1007/978-1-4613-0941-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8256-3

  • Online ISBN: 978-1-4613-0941-3

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