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Endothelial Cell Biology in Health and Disease pp 431–449Cite as

Response of Blood Vessel Cells to Viral Infection

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Abstract

Injury to blood vessel cells has been implicated in the development of a variety of vascular disorders including atherosclerosis,2’13 disseminated intravascular coagulation, 7 and immune vasculitis.44 Endothelial cell (EC) injury can arise from a variety of causes including hemodynamic stress,50 mechanical trauma,51 hypercholesterolemia, 45 infectious agents,14,39,42 oxygen,28 and other chemical agents such as homocysteine.56 Renewed interest in the relationship between vascular injury due to viral infection and atherosclerosis stems from recent observations which demonstrated that virus particles, virus antigens, and virus DNA can be detected in vascular lesions of chickens9,39 and humans4,21,38 with atherosclerosis. Viruses may produce vascular injury by mechanisms other than direct invasion of endothelium. Antigen-antibody complexes involving hepatitis B surface antigen have been isolated from the sera of some patients with periarteritis nodosa.17 Tumor formation as a result of viral infection is another possible mechanism by which viruses may induce vascular disease as is the case with cytomegalovirus and Kaposi’s sarcoma.20

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Authors and Affiliations

  1. Connective Tissue Research Institute and Department of Medicine, University of Pennsylvania and University City Science Center, Philadelphia, Pennsylvania, 19104, USA

    Nicholas A. Kefalides

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  1. Nicholas A. Kefalides
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  1. Institute of Cellular Biology and Pathology, Bucharest, Romania

    Nicolae Simionescu  & Maya Simionescu  & 

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© 1988 Plenum Press, New York

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Kefalides, N.A. (1988). Response of Blood Vessel Cells to Viral Infection. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Biology in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0937-6_19

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  • DOI: https://doi.org/10.1007/978-1-4613-0937-6_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8254-9

  • Online ISBN: 978-1-4613-0937-6

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