Cholinergic Drugs and Human Cognitive Performance

  • B. J. Sahakian


Three major lines of investigation have given impetus to our understanding of the role of cholinergic transmission in human cognition: study of the effects of cholinomimetics and anticholinergic drugs on behavior of experimental animals, on cognitive function in normal human subjects, and in patients with dementia of the Alzheimer type, which is associated with degeneration of the cholinergic projection to hippocampus and neocortex. The literature in each of these areas will be reviewed selectively in an attempt to determine whether the reported varied effects of these agents on cognitive performance can be attributed to effects on a single or restricted number of behavioral processes, and to assess the clinical and applied value of this research.


Dichotic Listening Cholinergic Drug Cholinergic Agent Mnemonic Process Stimulus Sensitivity 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • B. J. Sahakian
    • 1
  1. 1.Section of Old Age Psychiatry, Department of Psychiatry, Institute of PsychiatryUniversity of LondonLondonEngland

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