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Neuropathological and Neurochemical Aspects of Alzheimer’s Disease

  • David M. A. Mann

Abstract

Alzheimer’s disease is a dementing disorder of insidious onset and inexorable progression (see Blessed, 1980, for a review of clinical features). It has an age-dependent onset and is believed to affect some 10–15% of the population over 65 years of age and 20% of those over 80 years of age (see Terry and Katzman, 1983, for a review). Despite its distinctive clinical course, other pathologies causing similar clinical features make definitive diagnosis of Alzheimer’s disease uncertain without neuropathological confirmation. The usual histological criteria for diagnosis are the presence of abundant neuritic or senile plaques (SP) and nerve cells containing neurofibrillary tangles (NFT) within the neocortex and hippocampus.

Keywords

Neurofibrillary Tangle Senile Plaque Amyloid Fibril Nucleus Basalis Alzheimer Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David M. A. Mann
    • 1
  1. 1.Department of PathologyUniversity of ManchesterManchesterEngland

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