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Acute Ganglioside Effects Limit CNS Injury

Functional and Biochemical Consequences

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Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury

Abstract

There are many reports that ganglioside treatment of animals following CNS injury results in facilitated recovery. One mechanism by which gangliosides promote recovery may be their acute effect (“protection”) on early injury processes. We have found that within 48 hr after CNS injury (e.g., lesions, ablations, denervation, ischemia), there are reduced (1) behavioral deficits, (2) edema, (3) losses of membrane Na+, K+ -ATPase activity, and (4) mortality. The data support the hypothesis that ganglioside administration may be preserving membrane structure, thereby limiting the extent of CNS damage at the time of injury and providing optimal conditions for subsequent CNS recovery and repair (i.e., plasticity).

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Author information

Authors and Affiliations

  1. Division of Nueroscience, New York State Psychiatric Institute, New York, 10032, New York, USA

    Stephen E. Karpiak, Yu S. Li & Sahebarao P. Mahadik

  2. Departments of Psychiatry and Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, 10032, New York, USA

    Stephen E. Karpiak, Yu S. Li & Sahebarao P. Mahadik

Authors
  1. Stephen E. Karpiak
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  2. Yu S. Li
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  3. Sahebarao P. Mahadik
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Editor information

Editors and Affiliations

  1. Clark University, Massachusetts, Worcester, USA

    Donald G. Stein

  2. University of Munich, Munich, Federal Republic of Germany

    Bernhard A. Sabel

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© 1988 Plenum Press

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Karpiak, S.E., Li, Y.S., Mahadik, S.P. (1988). Acute Ganglioside Effects Limit CNS Injury. In: Stein, D.G., Sabel, B.A. (eds) Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0927-7_11

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  • DOI: https://doi.org/10.1007/978-1-4613-0927-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8249-5

  • Online ISBN: 978-1-4613-0927-7

  • eBook Packages: Springer Book Archive

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