Cortical Monoamines and Injured Brain
It is well established that brain injury which causes gross damage to vascular elements results in opening of the blood-brain barrier and an extravasation of fluid, giving rise to vasogenic edema (Katzman and Pappius, 1973). The edema has been generally accepted as the underlying cause of functional disturbances in conditions in which it occurs, although this assumption has not been validated and has been questioned (Pappius and McCann, 1969; Sutton et al., 1980; Pappius and Wolfe, 1984). On the other hand, brain injury is associated with many other events all of which can be envisaged as leading to disturbances of neuronal function independently of the develop-ment of cerebral edema (Pappius and Wolfe, 1984). These include release of arachidonic acid from membrane phospholipids and formation of prostaglandins and thromboxanes (Wolfe, 1982), release of neurotransmitters (Fenske et al., 1976; Bareggi et al., 1975; Vecht et al., 1975) and possibly the generation of free radicals (Demopoulos et al., 1972). In the context of this sym-posium, effects of injury on neurotransmitter systems are of particular interest.
KeywordsBiogenic Amine Glucose Utilization Vasogenic Edema Injured Brain Functional Disturbance
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