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Synaptic Regulation of Locus Coeruleus Neuronal Activity

  • Chapter
Neurotransmitters and Cortical Function

Abstract

The noradrenergic innervation of the cerebral cortex, including both the neocortex (Moore and Card, 1984) and the hippocampus (Loy et al., 1980), appears to originate exclusively in the locus coeruleus (LC), a small nucleus in the pons. The release of noradrenaline (NA) in the cerebral cortex, and its ensuing actions, should therefore be governed by activity of the LC neurons, with the qualifications that NA might be releasable from axonal varicosities in the absence of action potentials, and that release of this transmitter may be modulated by several other neurotransmit–ters and biologically active substances (Weiner, 1979). An understanding of the control of activity of LC neurons might, then, provide some insight into the role of noradrenergic neurotransmission in the cerebral cortex, and in other areas. It is our purpose, therefore, to briefly review the factors which influence LC neuronal activity, including afferent pathways, neurotransmitters, and intrin–sic activity. For the analysis of some of these factors, we will refer particularly to our recent work using intracellularly recorded LC neurons grown in explant cultures.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada

    Kenneth C. Marshall & Paul G. Finlayson

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  1. Kenneth C. Marshall
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  2. Paul G. Finlayson
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Editors and Affiliations

  1. McGill University and Montreal Neurological Institute, Montreal, Quebec, Canada

    Massimo Avoli  & Pierre Gloor  & 

  2. University of Montreal, Montreal, Quebec, Canada

    Tomás A. Reader

  3. McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada

    Robert W. Dykes

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© 1988 Plenum Press, New York

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Marshall, K.C., Finlayson, P.G. (1988). Synaptic Regulation of Locus Coeruleus Neuronal Activity. In: Avoli, M., Reader, T.A., Dykes, R.W., Gloor, P. (eds) Neurotransmitters and Cortical Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0925-3_24

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  • DOI: https://doi.org/10.1007/978-1-4613-0925-3_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8248-8

  • Online ISBN: 978-1-4613-0925-3

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