Role of Free Radical Lipid Peroxidation in Burn and Endotoxin Shock

  • T. Yoshikawa
  • N. Yoshida
  • H. Miyagawa
  • T. Takemura
  • T. Tanigawa
  • M. Murakami
  • M. Kondo
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 139)

Abstract

Enhanced free radical generation leading to lipid peroxidation has been claimed to be associated with various disorders (Bulkey, 1983). There is considerable indirect evidence supporting a role for oxygen radicals in circulatory shock. Crowell et al. (1969) and Cunningham and Keaveny (1978) reported that allopurinol, a competitive inhibitor of xanthine oxidase, substantially increased the survival rate of dogs subjected to hemorrhagic shock. Severe burns result in both local and systemic hemodynamic changes (Gilmore and Handford, 1956; Wolfe and Miller, 1976; Adams et al., 1981), as well as in endocrine (Turinsky et al., 1977), neuroendocrine (Cova and Glaviano, 1968; Goodall and Moncrief, 1965), and metabolic (Robinson and Miller, 1981; Wolfe et al., 1977) alterations. Acute endotoxin shock is rapidly produced with Escherichia coli endotoxin (Balis et al., 1978).

Keywords

Permeability Peroxide Hydroxyl Propane Superoxide 

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • T. Yoshikawa
    • 1
  • N. Yoshida
    • 1
  • H. Miyagawa
    • 1
  • T. Takemura
    • 1
  • T. Tanigawa
    • 1
  • M. Murakami
    • 1
  • M. Kondo
    • 1
  1. 1.First Department of MedicineKyoto Prefectural University of MedicineKyotoJapan

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