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The Effect of BW 755C on Wound Healing in a Scald Burn Injury Pig Model-Morphological and Biochemical Findings

  • J. A. Bauer
  • P. Conzen
  • K. Wurster
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 139)

Abstract

The significance of the arachidonic acid metabolites as mediators of thermal lesions remains controversial (1,2,3). We have therefore examined the effect of BW 755C — a known inhibitor of cyclooxigenase and lipoxigenase-on wound healing. In this study 2 ndo scald burns effecting 20 % of the body surface of anesthetised pigs were induced (3). The effect of systemic administration of BW 755C (10 mg/kg/die)(n=7) five minutes following induction of the scald burn was compared with that of a control group (n=4).

Keywords

Wound Healing Burned Area Biochemical Finding Arachidonic Acid Metabolite Improve Wound Healing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Alexander F., Mathieson M., Teoh K.H.T., Huval W.V., Lelcuck S., Valeri C.R., Shepro D., Hechtman H.B. Arachidonic acid metabolites mediate early burn edema, J. Trauma, 8:709 (1984). CrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. A. Bauer
    • 1
  • P. Conzen
    • 2
  • K. Wurster
    • 3
  1. 1.Chirurgische Klinik Innenstadt und Chirurgische Poliklinik der Universität MunchenMünchen 2Germany
  2. 2.Institut für chirurg. Forschung der Univ. MünchenMünchen 70Germany
  3. 3.Lehrkrankenhauses Munchen-SchwabingPathologisches Institut des StädtMünchen 40Germany

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