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Biochemical Mediators in Acute Respiratory Distress Syndrome (ARDS) after Burning Injury

  • Conference paper
Lipid Mediators in the Immunology of Shock

Part of the book series: NATO ASI Series ((NSSA,volume 139))

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Summary

Seventeen burned patients, 5 of whom developed the adult respiratory distress syndrome (ARDS), were investigated. Occurrence of ARDS was correlated with the severity of burn in ARDS patients (UBS: 82±27) and non ARDS patients (UBS: 36 ± 18) respectively (p < 0.005) and with inhalation injury.

Blood samples were collected immediately after admission, 6 – 12 h after injury, am/pm the first day and every day during a fortnight. This prospective study demonstrated abnormal C3 consumption as measured by the C3d/C3 ration in all burned patients, not related to the presence of ARDS. A significant protease-antiprotease imbalance was found in ARDS and non ARDS patients: leukocyte elastase was increased throughout the observation period, L 2 macroglobulin drastically decreased especially in ARDS patients, L 1 proteinase inhibitor early decreased below normal levels in ARDS patients. Finally, we found a time course delayed but persisting acute phase response: C-reactive protein, haptoglobin and L 1 acid glycoprotein reached a plateau on about day 5–7.

These biochemical investigations give no evidence for a specific mediator for acute respiratory failure.

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Author information

Authors and Affiliations

  1. Dept. of Anesthesiology, University Hospital, Liège, Belgium

    M. E. Faymonville, M. Lamy & J. Micheels

  2. Dept. of Immunology, University Hospital, Brussels, Belgium

    J. Duchateau

  3. Lab. of Clinical Biology, Centre Hospitalier, Sainte-Ode, Belgium

    A. Adam

  4. Lab. of Radioimmunology, University of Liège, Belgium

    G. Deby-Dupont

  5. Dept. of Plastic Surgery, University Hospital, Liège, Belgium

    D. Jacquemin

Authors
  1. M. E. Faymonville
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  2. M. Lamy
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  3. J. Duchateau
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  4. A. Adam
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  5. G. Deby-Dupont
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  6. J. Micheels
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  7. D. Jacquemin
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Editor information

Editors and Affiliations

  1. Centre de Traitement des Brules, Hopital d’Instruction des Armees Percy, Clamart, France

    M. Paubert-Braquet

  2. Institut Henri Beaufour, Le Plessis-Robinson, France

    P. Braquet

  3. Longwood Area Trauma Center, Harvard Medical School, Boston, Massachusetts, USA

    B. Demling

  4. St. Thomas Hospital, Nashville, Tennessee, USA

    J. R. Fletcher

  5. Georgetown University Medical Center, Washington, D.C., USA

    M. Foegh

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© 1987 Plenum Press, New York

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Faymonville, M.E. et al. (1987). Biochemical Mediators in Acute Respiratory Distress Syndrome (ARDS) after Burning Injury. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_4

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  • DOI: https://doi.org/10.1007/978-1-4613-0919-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8245-7

  • Online ISBN: 978-1-4613-0919-2

  • eBook Packages: Springer Book Archive

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