Cellular Immune Function and Injury
Defects in cellular immune responsiveness have been repeatedly described in patients after serious injury or major burns1–10. The exact relationship between impairment of cellular immunity and septic complications in such injured patients is unknown. Nevertheless, there are several reports which indicate that clinical anergy in patients with major burns, for example, is significantly correlated with mortality, particularly with death from sepsis 4,5,10,11. A number of years ago, we reported anergy in patients after major burn injury was associated both with failure of circulating lymphocytes from such patients to respond normally to the T cell mitogens phytohemagglutinin (PHA) and Concanavalin A (Con A), and with the presence in the patients’ serum of circulating substances suppressive of activation of normal human T lymphocytes4.
KeywordsPeripheral Blood Mononuclear Cell Injured Patient Thermal Injury Antibody Formation Total Body Surface Area
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