Immune Function and Severe Infection

  • V. Andersen
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 139)


In patients with an acute bacterial infection such as meningococcal meningitis, lymphocyte proliferative responses in vitro are depressed soon after the onset of symptoms1. Responses to microbial antigens are more sensitive than the responses to mitogens such as phytohemagglutinin (PHA) and are as a rule completely suppressed during the acute stage. The response to suboptimal concentrations of PHA may be a more sensitive indicator of depressed lymphocyte function than when the usual dose is employed2.


Meningococcal Meningitis Microbial Antigen Lymphocyte Proliferative Response Lymphocyte Proliferation Assay Suboptimal Concentration 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • V. Andersen
    • 1
  1. 1.Laboratory of Medical Immunology, Department of Medicine TTA RigshospitaletUniversity HospitalCopenhagenDenmark

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