Immune Function and Severe Infection
In patients with an acute bacterial infection such as meningococcal meningitis, lymphocyte proliferative responses in vitro are depressed soon after the onset of symptoms1. Responses to microbial antigens are more sensitive than the responses to mitogens such as phytohemagglutinin (PHA) and are as a rule completely suppressed during the acute stage. The response to suboptimal concentrations of PHA may be a more sensitive indicator of depressed lymphocyte function than when the usual dose is employed2.
KeywordsMeningococcal Meningitis Microbial Antigen Lymphocyte Proliferative Response Lymphocyte Proliferation Assay Suboptimal Concentration
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