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Importance of Immune Function in Trauma for Survival

  • Conference paper
Lipid Mediators in the Immunology of Shock

Part of the book series: NATO ASI Series ((NSSA,volume 139))

Abstract

Trauma may manifest itself in a number of different ways, including thermal injury, blunt injury, and the injury associated with elective surgery. Each of these forms of trauma has been demonstrated to produce important changes in the immune response which are clearly secondary and which in the absence of compounding variables such as the complications of infection, shock, malnutrition etc. have a recovery period which is a function of the magnitude of the injury and the age of the patient. This chapter will review data on the immune system following trauma and integrate these acquired immune defects with the increased likelihood of developing infection as well as the influence of compounding variables on the evolution of these defects.

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References

  1. M.S. Slade, R.D. Simmons, E. Yunis, and L.J. Greenberg, Immunodepression after major surgery in normal patients, Surgery 78:363–372 (1975).

    PubMed  CAS  Google Scholar 

  2. G.A. McLoughlin, A.V. Wu, and I. Saporoschetz, et al, Correlation between anergy and a circulating immunosuppressive factor following major surgical trauma, Ann. Surg. 190:297–304 (1979).

    Article  PubMed  CAS  Google Scholar 

  3. J.B. Pietsch, J.L. Meakins, D. Gotto, and L.D. MacLean, Delayed hypersensitivity responses: The effect of surgery, J. Surg. Res. 22:228–230 (1977).

    Article  PubMed  CAS  Google Scholar 

  4. N.V. Christou, R. Superina, M. Broadhead, and J.L. Meakins, Post operative depression of host resistance; determinants and effects of peripheral protein sparing therapy, Surgery 92:786–792 (1982).

    PubMed  CAS  Google Scholar 

  5. H.M. Shizgal, C.A. Milne, and A.H. Spanier, The effect of nitrogen-sparing intravenously administered fluids on postoperative body composition, Surgery 85:496–503 (1979).

    PubMed  CAS  Google Scholar 

  6. J.B. O’Mahony, A.J. Mclrvine, S.B. Palder, et al, The effect of short term postoperative intravenous feeding upon cell-mediated immunity and serum suppressive activity in well nourished patients, Surg. Gyn. Obs. 159:27–32 (1984).

    Google Scholar 

  7. H. Mochizuki, O. Trocki, L. Don, et al, Mechanism of prevention of post burn hypermetabolism and catabolism by early enteral feeding, Ann. Surg. 200:297–310 (1984).

    Article  PubMed  CAS  Google Scholar 

  8. J.W. Alexander, C.K. Ogle, J.D. Stinnett, et al, A comparison of immunologic profiles and their influence on bacteremia in surgical patients with a high risk of infection, Surgery 86:343 (1979).

    Google Scholar 

  9. J.W. Alexander, and J.L. Meakins, A physiologic basis for opportunistic infection, Ann. Surg. 176:273–387 (1972).

    Article  CAS  Google Scholar 

  10. G.L. Warden, The use of plasma exchange in the management of thermally injured patients, chapter 14, in: “Traumatic injury: infection and other immunologic sequelae,” J.L. Neinnemann, ed., University Park Press, Baltimore (1983).

    Google Scholar 

  11. J.L. Meakins, A.P.H. McLean, R. Kelly, et al., Delayed hypersensitivity response and neutrophil, J. Trauma 18:240–247 (1978).

    Article  PubMed  CAS  Google Scholar 

  12. N.V. Christou, A.P.H. McLean, and J.L. Meakins, Host defence in blunt trauma: Interrelationships of kinetics of anergy and depressed neutrophil function, nutritional status and sepsis, J. Trauma 20:833–841 (1980).

    Article  PubMed  CAS  Google Scholar 

  13. N.V. Christou, and J.L. Meakins, Partial analysis and purification of the polymorphonuclear neutrophil chemotactic inhibitors in serum from anergic patients, Arch. Surg. 118:156–160 (1983).

    PubMed  CAS  Google Scholar 

  14. J.L. Ninnemann, Immune depression in burn and trauma patients: the role of circulating suppressors, chapter 3, in: “Traumatic injury: infection and other immunologic sequelae” J.L. Ninnemann, ed., University Park Press, Baltimore (1983).

    Google Scholar 

  15. J.L. Meakins, N.V. Christou, H.M. Shizgal and L.D. MacLean, Therapeutic approaches to anergy in surgical patients: Surgery and Levamisole, Ann. Surg. 190:285–296 (1979).

    Article  Google Scholar 

  16. J.S. Solomkin, L.A. Coha, O.K. Brodt, et al., Neutrophil dysfunction in Sepsis: III Degranulation as a mechanism for non specific deactivation. J. Surg. Res. 36:407–412 (1984).

    Article  PubMed  CAS  Google Scholar 

  17. M. Heideman, Bacteremia and multiple organ failure: The role of injured tissue and abscess, chapter 8, in: Traumatic injury: infection and other immunologic sequelae, J.L. Ninnemann, ed., University Park Press, Baltimore (1983).

    Google Scholar 

  18. W.O. Richards, W. Scovill, B. Shin, W. Reed, Oprsonic fibronectin deficiency in patients with intraabdominal infection. Surgery 94:210–7 (1983).

    PubMed  CAS  Google Scholar 

  19. A.W. Segal, and G. Loewi, Neutrophil dysfunction in Crohn’s disease, Lancet ii:219–221 (1976).

    Article  Google Scholar 

  20. R.A. Superina, N.V. Christou, M. Broadhead, et al, Relationship between disease activity index and host defense in patients with inflammatory bowel disease, Ann. Royal Coll. Phys. Surg. Canada 14 (abst) (1981).

    Google Scholar 

  21. J.I. Tchervenkov, E. Diano, 3.L. Meakins, and N.V. Christou, The delayed type hypersensitivity (DTH) skin test score (STS) accurately measures susceptibility to bacterial sepsis, Arch. Surg. (1986).

    Google Scholar 

  22. A.A. Miles, E.M. Miles and J. Burke, The value and duration of defense reactions of the skin to the primary lodgement of bacteria, Br. J. Exp. Path., 24:95–107 (1957).

    Google Scholar 

  23. M. McPhee, I. Zakaluzny, 3. Marshall, et al, Mixed lymphocyte culture (MLC) supernatants provide effective immunotherapy for accute peritonitis in immunosuppressed rats, Surgical Forum (in press) (1986).

    Google Scholar 

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© 1987 Plenum Press, New York

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Meakins, J.L. (1987). Importance of Immune Function in Trauma for Survival. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_29

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  • DOI: https://doi.org/10.1007/978-1-4613-0919-2_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8245-7

  • Online ISBN: 978-1-4613-0919-2

  • eBook Packages: Springer Book Archive

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