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Biogenic Amines: Microcirculatory Aspects in Shock, Sepsis and Trauma

  • D. H. Lewis
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 139)

Abstract

The purpose of this communication is to give a concise overview of the effect of shock, sepsis and trauma on the handling of biogenic amines in the body and also how these substances affect the organism exposed to these pathophysiologies. I will deal primarily with some of the microcirculatory phenomena and their mechanisms, and will not deal with the use of biogenic amines or their blockers in the therapy of these disorders. Further, I will consider only the monoamines, i.e. catecholamines (including epinephrine, norepinephrine and dopamine), serotonin (i.e.5-hydroxytryptamine) and histamine. To my knowledge, the effect of shock, sepsis and trauma on polyamines has not been studied. These substances are involved in cell differentiation and growth, and it is conceivable that disorders here could have long-term effects. For a review of these substances see Heby (1986). Since much more is known about the reactions of catecholamines than about serotonin and histamine, most emphasis will be placed on catecholamines.

Keywords

Biogenic Amine Plasma Catecholamine Circ Shock Cremaster Muscle Endotoxin Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • D. H. Lewis
    • 1
  1. 1.Clinical Research CenterUniversity HospitalLinköpingSweden

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