Abstract
Anaphylaxis in the guinea-pig is widely used as a model for human asthma. Nevertheless, no ultrastructural morphological studies of the anaphylactic shock in this animal were reported until now. Beside histamine, alternative mediators accounting for asthma have been incriminated, the peptido-leukotrienes first, and, more recently, PAF-acether was added to the list (Braquet et al, 1985; Page and Morley, 1986). This ether-linked phospholipid is known to induce various biological actions. It is also released during allergic reactions (Benveniste et al., 1972; Pinckard et al., 1979). PAF-acether administrated i.v. to the guinea-pig induces bronchoconstriction, which is histamine and cyclooxygenase-independent and platelet-dependent (Vargaftig et al., 1980). This is consistent with the fact that non-steroidal anti-inflammatory drugs are ineffective in clinical asthma.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Braquet, B., Etienne, A., Touvay, C., Bourgain, R.H., Lefort, J. and Vargaftig, B.B. Lancet 1(8444):1501 (1985).
Page, C.P. and Morley, Tharmacol. Res. Com. 18, Suppl: 217 (1986).
Benveniste, J., Henson, P.M. and Cochrane, C.G. J. Exp. Med. 136: 1356 (1972).
Pinkard, R.N., Farr, R.S. and Hanahan, D.J. J. Immunol. 123: 1847 (1979).
Vargaftig, B.B., Lefort, J., Chignard, M. and Benveniste, J. Eur. J. Pharmacol. 65: 185 (1980).
Lellouch-Tubiana, A., Lefort, J., Pirotzky, E., Vargaftig, B.B. and Pfister, A. Brit. J. exp. Path. 66: 345 (1985).
Andersson, P. and Bergstrand, H. Br. J. Pharmacol. 74: 601 (1981).
Lefort, J. and Vargaftig, B.B. Br. J. Pharmacol. 63: 35 (1978).
Cirino, M., Lagente, V., Lefort, J. and Vargaftig, B.B. Prostaglandins, in press.
Lefort, J., Rotilio, D. and Vargaftig, B.B., Br. J. Pharmacol. 82:565 (1984).
Basran, G.S., Dewar, A., Morley, J., Page, C.P., Paul, W., Wood, L.E. Br. J. Pharmacol. 77: 437P (1982).
Kallos, P. and Kallos, L. Int. Archs. Allergy & appl. Immunol. 73:77 (1984).
Frigas, E. and Gleich, G.J. J. Allergy Clin. Immunol. 77: 527 (1986).
Bourgain, R.H., Andries, R., Braquet, P. and Deby, C. Prostaglandins 30: 915 (1985).
Maridonneau-Parini, I., Lagente, V., Lefort, J., Randon, J., Russo-Marie, F. and Vargaftig, B.B. Biochem. Biophys. Res. Commun. 131: 42 (1985).
Capron, M., Kusnierz, J.P., Prin, L., Spegelley, H.L., Klahife, J., Tonnel, A.B. and Capron, A. Int. Archs. Allergy appli. Immunol.77: 246 (1985).
Wardlaw, A. J. and Kay, A.B. J. Allergy clin. Immunol.77: 236 (1986).
Henocq, E. and Vargaftig, B.B. Lancet 11: 1378 (1986).
Spry, C.J.F. Immun. Today 6: 332 (1985).
Kay, A.B., Wardlaw, A.F., Mogbel, R., Buchanan, D.R. and Cromwell, O. in Proceedings of 1986 Symposium on “Allergy and Inflammation” (Academic Press).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this paper
Cite this paper
Lellouch-Tubiana, A., Lefort, J., Lagente, V., Cirino, M., Vargaftig, M., Vargaftig, B.B. (1987). Morphological and Pharmacological Evidences for the Participation of PAF-Acether in Anaphylactic Shock in the Guinea-Pig. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_22
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0919-2_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8245-7
Online ISBN: 978-1-4613-0919-2
eBook Packages: Springer Book Archive