Mechanisms of Circulatory Collapse Induced by PAF-Acether

  • R. E. Goldstein
  • F. R. M. Laurindo
  • D. Ezra
  • G. Z. Feuerstein
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 139)

Abstract

PAF-acether (l-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) is an inflammatory mediator with potent circulatory actions (1). Release of this agent by activated leukocytes, macrophages, platelets, and thrombin-stimulated endothelial cells is likely to occur during Ig-E related anaphylaxis or sepsis. Adverse effects of PAF-acether may contribute significantly to circulatory deterioration and collapse that can accompany these conditions.

Keywords

Catheter Depression Ischemia Lactate Polypeptide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Benveniste J and Chignard M. Circulation 72:713 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    Kamitani T, Katamoto M, Tasumi M, Katsuta K, Ono T, Kikuchi H, and Kumada S. Eur J Pharmacol 98:357 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    Cervoni P, Herzlinger HE, Lai FM, and Tanikella TE. Br J Pharmacol 79:667 (1983).PubMedGoogle Scholar
  4. 4.
    Benveniste J, Boullet C, Brink C, and Labat C. Br J Pharmacol 80:81(1983).PubMedGoogle Scholar
  5. 5.
    Levi R, Burke JA, Guo LG, Hattori Y, Hoppens CM, McManus LM, Hanahan DJ, and Pinckard PN. Circ Res 54:117 (1984).PubMedGoogle Scholar
  6. 6.
    Bessin P, Bonnet J, Apffel D, Soulard C, Desgroux L, Pelas I, and Benveniste J. Eur J Pharmacol 86:403 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    Kenzora JL, Perez JE, Bergmann SR, and Lange LG. J Clin Invest 74:1193 (1984).PubMedCrossRefGoogle Scholar
  8. 8.
    Lefer AM, Mueller HF, and Smith JB. Br J Pharmacol 83:125 (1984).PubMedGoogle Scholar
  9. 9.
    Sybertz EJ, Watkins RW, Baum T, Pula K, and Rivelli M. J Pharmacol Exp Ther 232:156 (1985).PubMedGoogle Scholar
  10. 10.
    Feuerstein GZ, Boyd LM, Ezra D, and Goldstein RE. Am J Physiol 246:H466 (1984).PubMedGoogle Scholar
  11. 11.
    Feuerstein GZ, Ezra D, Ramwell PW, Letts G, and Goldstein RE in: Prostaglandins, Leukotrienes, and Lipoxins (editor: JM Bailey). Plenum (NY) p 301 (1985).Google Scholar
  12. 12.
    Jackson CV, Schumacher WA, Kunkel SL, Driscoll EM, and Lucchesi BR. Circ Res 58:218 (1986).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. E. Goldstein
    • 1
  • F. R. M. Laurindo
    • 1
  • D. Ezra
    • 1
  • G. Z. Feuerstein
    • 1
  1. 1.Divisions of Cardiology and Clinical Pharmacology and Neurobiology Research Unit, Departments of Medicine, Pharmacology, and NeurologyUniformed Services University of Health Sciences BethesdaUSA

Personalised recommendations