Mechanisms of Circulatory Collapse Induced by PAF-Acether

  • R. E. Goldstein
  • F. R. M. Laurindo
  • D. Ezra
  • G. Z. Feuerstein
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 139)


PAF-acether (l-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) is an inflammatory mediator with potent circulatory actions (1). Release of this agent by activated leukocytes, macrophages, platelets, and thrombin-stimulated endothelial cells is likely to occur during Ig-E related anaphylaxis or sepsis. Adverse effects of PAF-acether may contribute significantly to circulatory deterioration and collapse that can accompany these conditions.


Left Anterior Descend Pulmonary Artery Pressure Pulmonary Vascular Resistance Coronary Blood Flow Systemic Arterial Pressure 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. E. Goldstein
    • 1
  • F. R. M. Laurindo
    • 1
  • D. Ezra
    • 1
  • G. Z. Feuerstein
    • 1
  1. 1.Divisions of Cardiology and Clinical Pharmacology and Neurobiology Research Unit, Departments of Medicine, Pharmacology, and NeurologyUniformed Services University of Health Sciences BethesdaUSA

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