Mechanisms of Circulatory Collapse Induced by PAF-Acether
PAF-acether (l-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) is an inflammatory mediator with potent circulatory actions (1). Release of this agent by activated leukocytes, macrophages, platelets, and thrombin-stimulated endothelial cells is likely to occur during Ig-E related anaphylaxis or sepsis. Adverse effects of PAF-acether may contribute significantly to circulatory deterioration and collapse that can accompany these conditions.
KeywordsCatheter Depression Ischemia Lactate Polypeptide
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